3S3F

Crystal Structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecule inhibitor Vanadate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tyrosine-protein phosphatase 10D	polymer	307	35945.6	2	UniProt (P35992) Pfam (PF00102) In PDB	Drosophila melanogaster (Fruit fly)	Receptor-linked protein-tyrosine phosphatase 10D, DPTP10D
2	A, B	1-BUTANOL	non-polymer		74.1	2	Chemie (1BO)
3	A	ISOPROPYL ALCOHOL	non-polymer		60.1	2	Chemie (IPA)
4	B	VANADATE ION	non-polymer		114.9	1	Chemie (VO4)
5	B	1,4-BUTANEDIOL	non-polymer		90.1	1	Chemie (BU1)
6		water	water		18.0	90	Chemie (HOH)

Sequence modifications

A, B: 24 - 307 (UniProt: P35992)

PDB	External Database	Details
Met 1	-	expression tag
Gly 2	-	expression tag
Ser 3	-	expression tag
Ser 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Ser 11	-	expression tag
Ser 12	-	expression tag
Gly 13	-	expression tag
Leu 14	-	expression tag
Val 15	-	expression tag
Pro 16	-	expression tag
Arg 17	-	expression tag
Gly 18	-	expression tag
Ser 19	-	expression tag
His 20	-	expression tag
Met 21	-	expression tag
Ala 22	-	expression tag
Ser 23	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	71891.3
Non-Polymers*	Number of molecules	6
	Total formula weight	473.5
All*	Total formula weight	72364.8

*Water molecules are not included.