3S3F

Crystal Structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecule inhibitor Vanadate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation
B	0004725	molecular_function	protein tyrosine phosphatase activity
B	0006470	biological_process	protein dephosphorylation
B	0016311	biological_process	dephosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE 1BO A 308

Chain	Residue
A	HIS20

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IPA A 309

Chain	Residue
A	LEU80

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IPA A 310

Chain	Residue
A	ASP178
A	SER179
A	HIS180

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE VO4 B 308

Chain	Residue
B	LYS154
B	SER243
B	ALA244

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BU1 B 309

Chain	Residue
B	ASN110
B	SER111
B	PRO112
B	GLY108

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 1BO B 310

Chain	Residue
B	ILE262
B	ASN263

---

Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRSG

Chain	Residue	Details
A	VAL240-GLY250

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	510
Details	Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10044","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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