3RZE

Structure of the human histamine H1 receptor in complex with doxepin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Histamine H1 receptor, Lysozyme chimera	polymer	452	52382.6	1	UniProt (P35367) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) In PDB	Homo sapiens (human)	H1R, HH1R, Endolysin, Lysis protein, Muramidase
2	A	(3E)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine	non-polymer		279.4	1	Chemie (5EH)
3	A	(3Z)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine	non-polymer		279.4	1	Chemie (D7V)
4	A	PHOSPHATE ION	non-polymer		95.0	3	Chemie (PO4)
5	A	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	1	Chemie (OLC)
6		water	water		18.0	2	Chemie (HOH)

Sequence modifications

A: 20 - 221 (UniProt: P35367)
A: 1002 - 1161 (UniProt: P00720)

PDB	External Database	Details
Thr 1054	Cys 54	engineered mutation
Ala 1097	Cys 97	engineered mutation

A: 405 - 487 (UniProt: P35367)

PDB	External Database	Details
Gly 488	-	expression tag
Glu 489	-	expression tag
Asn 490	-	expression tag
Leu 491	-	expression tag
Tyr 492	-	expression tag
Phe 493	-	expression tag
Gln 494	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52382.6
Non-Polymers*	Number of molecules	6
	Total formula weight	1200.2
All*	Total formula weight	53582.8

*Water molecules are not included.