3RZE

Structure of the human histamine H1 receptor in complex with doxepin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016998	biological_process	cell wall macromolecule catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 5EH A 1200

Chain	Residue
A	ASP107
A	TYR108
A	SER111
A	THR112
A	TRP158
A	TRP428
A	TYR431
A	PHE432
A	TYR458

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE D7V A 1201

Chain	Residue
A	ASP107
A	TYR108
A	SER111
A	THR112
A	ILE115
A	TRP158
A	ASN198
A	TRP428
A	TYR431
A	PHE432
A	PHE435
A	TYR458

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 1202

Chain	Residue
A	ASP178
A	LYS179
A	LYS191
A	TYR431
A	PHE435
A	HIS450

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 A 1203

Chain	Residue
A	ARG1076
A	ARG1080

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 1204

Chain	Residue
A	THR1142
A	PRO1143
A	ASN1144
A	ARG1145

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OLC A 1205

Chain	Residue
A	GLU1011
A	ARG1014
A	ASN1053
A	ASN1055

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIfSVFILCIDRYRsV

Chain	Residue	Details
A	ALA113-VAL129

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	LEU30-VAL52

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:21697825

Chain	Residue	Details
A	ARG53-GLY62
A	ASP124-ARG143
A	CYS471-SER487

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	ASN63-MET83

---

site_id	SWS_FT_FI4
Number of Residues	52
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:21697825

Chain	Residue	Details
A	ASN84-LEU101
A	TRP165-TRP189
A	ALA439-HIS450

---

site_id	SWS_FT_FI5
Number of Residues	21
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	PHE102-ILE123

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ALA144-GLY164

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	PHE190-TYR210

---

site_id	SWS_FT_FI8
Number of Residues	21
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	LEU417-ILE438

---

site_id	SWS_FT_FI9
Number of Residues	19
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	MET451-LEU470

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:15328002

Chain	Residue	Details
A	THR140
A	THR142

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	GLU1011

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	ASP1020

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	LEU1032
A	PHE1104

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	BINDING: BINDING => ECO:0000303|PubMed:7831309

Chain	Residue	Details
A	SER1117
A	ASN1132

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
A	GLU1011	proton shuttle (general acid/base)
A	ASP1020	covalent catalysis

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