3RY6
Complex of fcgammariia (CD32) and the FC of human IGG1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ig gamma-1 chain C region | polymer | 214 | 24244.5 | 2 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (human) | FC OF HUMAN IGG1, HEAVY CHAIN |
| 2 | C (C) | Low affinity immunoglobulin gamma Fc region receptor II-a | polymer | 167 | 18881.1 | 1 | UniProt (P12318) Pfam (PF13895) | Homo sapiens (human) | IgG Fc receptor II-a, CDw32, Fc-gamma RII-a, Fc-gamma-RIIa, FcRII-a |
| 3 | D (D) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-alpha-D-glucopyranose | branched | 1916.7 | 1 | In PDB GlyTouCan (G91345JE) | |||
| 4 | E (E) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 2370.1 | 1 | In PDB GlyTouCan (G11745XZ) | |||
| 5 | F (F) | beta-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-alpha-D-glucopyranose | branched | 1057.0 | 1 | In PDB GlyTouCan (G05484KA) | |||
| 6 | G, H, I, J (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 7 | K (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
A, B: 231 - 444 (UniProt: P01857)
C: 7 - 173 (UniProt: P12318)
| PDB | External Database | Details |
|---|---|---|
| Gln 272 | Glu 155 | SEE REMARK 999 |
| Gln 283 | Glu 166 | SEE REMARK 999 |
| Gln 294 | Glu 177 | SEE REMARK 999 |
| Asn 312 | Asp 195 | SEE REMARK 999 |
| Asp 315 | Asn 198 | SEE REMARK 999 |
| Glu 356 | Asp 239 | variant |
| Met 358 | Leu 241 | variant |
| PDB | External Database | Details |
|---|---|---|
| Arg 134 | His 167 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 67370.0 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 5343.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 589.6 | |
| All* | Total formula weight | 73303.4 |
