3RNN

Crystal Structure of iGluR2 Ligand Binding Domain with Symmetric Sulfonamide Containing Potentiator

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Glutamate receptor 2	polymer	292	32035.7	3	UniProt (P42262) Pfam (PF10613) Pfam (PF00060)	Homo sapiens (human)	GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2
2	D, G (A, B)	N,N'-(benzene-1,4-diyldiethane-2,1-diyl)dipropane-2-sulfonamide	non-polymer		376.5	2	Chemie (RNN)
3	E, H, K (A, B, C)	GLUTAMIC ACID	non-polymer		147.1	3	Chemie (GLU)
4	F, I, J, L, M (A, B, C)	ZINC ION	non-polymer		65.4	5	Chemie (ZN)
5	N, O, P (A, B, C)	water	water		18.0	835	Chemie (HOH)

Sequence modifications

A, B, C: 3 - 117 (UniProt: P42262)

PDB	External Database	Details
Arg -12	-	expression tag
Gly -11	-	expression tag
Ser -10	-	expression tag
Ala -9	-	expression tag
Met -8	-	expression tag
Gly -7	-	expression tag
Ser -6	-	expression tag
Gly -5	-	expression tag
Asn -4	-	expression tag
Asp -3	-	expression tag
Thr -2	-	expression tag
Ser -1	-	expression tag
Arg 0	-	expression tag
Gly 1	-	expression tag
Ala 2	-	expression tag

A, B, C: 120 - 279 (UniProt: P42262)

PDB	External Database	Details
Gly 118	-	linker
Thr 119	-	linker
Gly 231	Arg 764	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	96107.0
Non-Polymers*	Number of molecules	10
	Total formula weight	1521.5
All*	Total formula weight	97628.5

*Water molecules are not included.