3RNN

Crystal Structure of iGluR2 Ligand Binding Domain with Symmetric Sulfonamide Containing Potentiator

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE RNN A 280

Chain	Residue
A	LYS104
C	GLY219
A	PRO105
A	SER108
A	LYS218
A	GLY219
A	LEU239
C	LYS104
C	PRO105
C	LYS218

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLU A 281

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193
A	HOH286
A	HOH287
A	HOH294

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 282

Chain	Residue
A	GLU42
A	HIS46
B	GLU166

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE RNN B 280

Chain	Residue
B	LYS104
B	LYS104
B	PRO105
B	PRO105
B	SER108
B	SER108
B	LYS218
B	LYS218
B	GLY219
B	GLY219
B	LEU239
B	LEU239
B	ASN242

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 281

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143
B	GLU193
B	HOH288
B	HOH304
B	HOH311

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 282

Chain	Residue
B	HIS23
B	GLU30
C	HIS23
C	GLU24

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 283

Chain	Residue
A	GLU166
B	GLU42
B	HIS46
B	LEU241
B	HOH478

---

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU C 280

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	LEU138
C	GLY141
C	SER142
C	THR143
C	GLU193
C	HOH283
C	HOH297
C	HOH321

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 281

Chain	Residue
A	HIS23
C	ASP65
C	HOH490
C	HOH491

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 282

Chain	Residue
C	GLU42
C	LYS45
C	HIS46
C	HOH806

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:20614889, ECO:0007744|PDB:2XHD

Chain	Residue	Details
A	PRO89
C	THR91
C	SER142
C	THR143
A	THR91
A	SER142
A	THR143
B	PRO89
B	THR91
B	SER142
B	THR143
C	PRO89

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:20614889, ECO:0000269|PubMed:21531559, ECO:0007744|PDB:2XHD, ECO:0007744|PDB:3R7X

Chain	Residue	Details
A	ARG96
B	ARG96
C	ARG96

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:20614889, ECO:0000269|PubMed:21531559, ECO:0007744|PDB:2XHD

Chain	Residue	Details
A	GLU193
B	GLU193
C	GLU193

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:P19491

Chain	Residue	Details
A	SER150
B	SER150
C	SER150

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000250|UniProtKB:P19491

Chain	Residue	Details
A	SER184
B	SER184
C	SER184

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3

---