3RL0

Truncated SNARE complex with complexin (P1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, I, M, Q...	Vesicle-associated membrane protein 2	polymer	37	4254.8	8	UniProt (P63027) Pfam (PF00957) In PDB	Homo sapiens (human)	VAMP-2, Synaptobrevin-2
2	B, F, J, N, R...	Syntaxin-1A	polymer	65	7551.5	8	UniProt (P32851) Pfam (PF05739) In PDB	Rattus norvegicus (brown rat rat rats)	Neuron-specific antigen HPC-1, Synaptotagmin-associated 35 kDa protein, P35A
3	C, G, K, O, S...	Synaptosomal-associated protein 25	polymer	81	9500.6	8	UniProt (P60880) In PDB	Homo sapiens (human)	SNAP-25, Super protein, SUP, Synaptosomal-associated 25 kDa protein
4	D, H, L, P, T...	Synaptosomal-associated protein 25	polymer	65	7427.3	8	UniProt (P60880) In PDB	Homo sapiens (human)	SNAP-25, Super protein, SUP, Synaptosomal-associated 25 kDa protein
5	g, h, i, j, k...	Complexin-1	polymer	63	7313.0	8	UniProt (O14810) Pfam (PF05835) In PDB	Homo sapiens (human)	Complexin I, CPX I, Synaphin-2

Sequence modifications

A, E, I, M, Q, U, Y, c: 28 - 60 (UniProt: P63027)

PDB	External Database	Details
Gly 24	-	EXPRESSION TAG
Pro 25	-	EXPRESSION TAG
Leu 26	-	EXPRESSION TAG
Gly 27	-	EXPRESSION TAG

B, F, J, N, R, V, Z, d: 191 - 253 (UniProt: P32851)

PDB	External Database	Details
Gly 189	-	EXPRESSION TAG
Ser 190	-	EXPRESSION TAG

C, G, K, O, S, W, a, e: 7 - 82 (UniProt: P60880)

PDB	External Database	Details
Gly 3	-	EXPRESSION TAG
Ser 4	-	EXPRESSION TAG
His 5	-	EXPRESSION TAG
Met 6	-	EXPRESSION TAG
Trp 83	-	EXPRESSION TAG

D, H, L, P, T, X, b, f: 141 - 203 (UniProt: P60880)

PDB	External Database	Details
Gly 139	-	EXPRESSION TAG
Ser 140	-	EXPRESSION TAG

g, h, i, j, k, l, m, n: 26 - 83 (UniProt: O14810)

PDB	External Database	Details
Gly 21	-	EXPRESSION TAG
Pro 22	-	EXPRESSION TAG
Leu 23	-	EXPRESSION TAG
Gly 24	-	EXPRESSION TAG
Ser 25	-	EXPRESSION TAG
Leu 27	Asp 27	ENGINEERED MUTATION
Mse 34	Glu 34	ENGINEERED MUTATION
Ala 37	Arg 37	ENGINEERED MUTATION

Contents of the asymmetric unit

Polymers	Number of chains	40
	Total formula weight	288377.2
All*	Total formula weight	288377.2

*Water molecules are not included.