3QT2

Structure of a cytokine ligand-receptor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, B)	Interleukin-5 receptor subunit alpha	polymer	317	36117.7	2	UniProt (Q01344) Pfam (PF09240)	Homo sapiens (human)	IL-5 receptor subunit alpha, IL-5R subunit alpha, IL-5R-alpha, IL-5RA, CDw125
2	B, C, E, F (C, D, E, F)	Interleukin-5	polymer	117	13368.5	4	UniProt (P05113) Pfam (PF02025)	Homo sapiens (human)	IL-5, B-cell differentiation factor I, Eosinophil differentiation factor, T-cell replacing factor, TRF
3	G, H, I, K, L... (A, B)	beta-D-glucopyranose	non-polymer		180.2	6	Chemie (BGC)
4	J (A)	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	1	Chemie (MPD)
5	N, O, P, Q, R... (A, C, D, B, E...)	water	water		18.0	55	Chemie (HOH)

Sequence modifications

A, B: 0 - 315 (UniProt: Q01344)

PDB	External Database	Details
Met -1	-	expression tag
Ala 66	Cys 86	engineered mutation
Met 72	Lys 92	engineered mutation
Met 138	Leu 158	engineered mutation
Met 167	Lys 187	engineered mutation
Met 234	Leu 254	engineered mutation
Phe 313	Asn 333	SEE REMARK 999
Ser 314	Asp 334	SEE REMARK 999
Arg 315	Glu 335	SEE REMARK 999

C, D, E, F: 0 - 115 (UniProt: P05113)

PDB	External Database	Details
Met -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	125709.3
Non-Polymers*	Number of molecules	7
	Total formula weight	1199.1
All*	Total formula weight	126908.4

*Water molecules are not included.