3QAZ
IL-2 mutant D10 ternary complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, BA, D, EA, G... (A, D, G, J, M...) | Interleukin-2 | polymer | 136 | 15727.2 | 12 | UniProt (P60568) Pfam (PF00715) | Homo sapiens (human) | IL-2, T-cell growth factor, TCGF |
| 2 | B, CA, E, FA, H... (B, E, H, K, N...) | Interleukin-2 receptor subunit beta | polymer | 217 | 25044.4 | 12 | UniProt (P14784) Pfam (PF18707) | Homo sapiens (human) | IL-2 receptor subunit beta, IL-2R subunit beta, IL-2RB, High affinity IL-2 receptor subunit beta, p70-75, p75 |
| 3 | AA, C, DA, F, GA... (C, F, I, L, O...) | Cytokine receptor common subunit gamma | polymer | 202 | 24196.0 | 12 | UniProt (P31785) Pfam (PF22012) Pfam (PF21605) | Homo sapiens (human) | Interleukin-2 receptor subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, IL-2RG, p64 |
| 4 | AB, AC, BB, BC, CB... (I, Z, a, K, c...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 54 | Chemie (NAG) |
Sequence modifications
A, D, G, J, M, P, S, V, Y, b, e, h: 1 - 133 (UniProt: P60568)
B, E, H, K, N, Q, T, W, Z, c, f, i: -2 - 214 (UniProt: P14784)
C, F, I, L, O, R, U, X, a, d, g, j: 34 - 232 (UniProt: P31785)
| PDB | External Database | Details |
|---|---|---|
| Ala -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Pro 0 | - | expression tag |
| His 74 | Gln 94 | engineered mutation |
| Phe 80 | Leu 100 | engineered mutation |
| Asp 81 | Arg 101 | engineered mutation |
| Val 85 | Leu 105 | engineered mutation |
| Val 86 | Ile 106 | engineered mutation |
| Phe 92 | Ile 112 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asp -1 | Ser 25 | engineered mutation |
| Pro 0 | Ala 26 | engineered mutation |
| Gln 3 | Asn 29 | engineered mutation |
| Gln 17 | Asn 43 | engineered mutation |
| Gln 45 | Asn 71 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 31 | - | expression tag |
| Asp 32 | - | expression tag |
| Pro 33 | - | expression tag |
| Gln 53 | Asn 75 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 36 |
| Total formula weight | 779610.2 | |
| Non-Polymers* | Number of molecules | 54 |
| Total formula weight | 11945.2 | |
| All* | Total formula weight | 791555.4 |
