3QAZ

IL-2 mutant D10 ternary complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0002366	biological_process	leukocyte activation involved in immune response
A	0002376	biological_process	immune system process
A	0002639	biological_process	positive regulation of immunoglobulin production
A	0002903	biological_process	negative regulation of B cell apoptotic process
A	0005125	molecular_function	cytokine activity
A	0005134	molecular_function	interleukin-2 receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006366	biological_process	transcription by RNA polymerase II
A	0006955	biological_process	immune response
A	0007155	biological_process	cell adhesion
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0007267	biological_process	cell-cell signaling
A	0008083	molecular_function	growth factor activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0010467	biological_process	gene expression
A	0019209	molecular_function	kinase activator activity
A	0030101	biological_process	natural killer cell activation
A	0030217	biological_process	T cell differentiation
A	0030246	molecular_function	carbohydrate binding
A	0030307	biological_process	positive regulation of cell growth
A	0030890	biological_process	positive regulation of B cell proliferation
A	0031851	molecular_function	kappa-type opioid receptor binding
A	0032729	biological_process	positive regulation of type II interferon production
A	0032740	biological_process	positive regulation of interleukin-17 production
A	0034105	biological_process	positive regulation of tissue remodeling
A	0038110	biological_process	interleukin-2-mediated signaling pathway
A	0042098	biological_process	T cell proliferation
A	0042102	biological_process	positive regulation of T cell proliferation
A	0042104	biological_process	positive regulation of activated T cell proliferation
A	0043066	biological_process	negative regulation of apoptotic process
A	0043208	molecular_function	glycosphingolipid binding
A	0045471	biological_process	response to ethanol
A	0045582	biological_process	positive regulation of T cell differentiation
A	0045591	biological_process	positive regulation of regulatory T cell differentiation
A	0045621	biological_process	positive regulation of lymphocyte differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046013	biological_process	regulation of T cell homeostatic proliferation
A	0046651	biological_process	lymphocyte proliferation
A	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
A	0050672	biological_process	negative regulation of lymphocyte proliferation
A	0050728	biological_process	negative regulation of inflammatory response
A	0050729	biological_process	positive regulation of inflammatory response
A	0050798	biological_process	activated T cell proliferation
A	0060999	biological_process	positive regulation of dendritic spine development
A	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
A	0097696	biological_process	cell surface receptor signaling pathway via STAT
A	1900100	biological_process	positive regulation of plasma cell differentiation
A	1901327	biological_process	response to tacrolimus
A	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
A	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
B	0004896	molecular_function	cytokine receptor activity
B	0016020	cellular_component	membrane
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane
D	0002250	biological_process	adaptive immune response
D	0002366	biological_process	leukocyte activation involved in immune response
D	0002376	biological_process	immune system process
D	0002639	biological_process	positive regulation of immunoglobulin production
D	0002903	biological_process	negative regulation of B cell apoptotic process
D	0005125	molecular_function	cytokine activity
D	0005134	molecular_function	interleukin-2 receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006366	biological_process	transcription by RNA polymerase II
D	0006955	biological_process	immune response
D	0007155	biological_process	cell adhesion
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
D	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
D	0007267	biological_process	cell-cell signaling
D	0008083	molecular_function	growth factor activity
D	0008284	biological_process	positive regulation of cell population proliferation
D	0010467	biological_process	gene expression
D	0019209	molecular_function	kinase activator activity
D	0030101	biological_process	natural killer cell activation
D	0030217	biological_process	T cell differentiation
D	0030246	molecular_function	carbohydrate binding
D	0030307	biological_process	positive regulation of cell growth
D	0030890	biological_process	positive regulation of B cell proliferation
D	0031851	molecular_function	kappa-type opioid receptor binding
D	0032729	biological_process	positive regulation of type II interferon production
D	0032740	biological_process	positive regulation of interleukin-17 production
D	0034105	biological_process	positive regulation of tissue remodeling
D	0038110	biological_process	interleukin-2-mediated signaling pathway
D	0042098	biological_process	T cell proliferation
D	0042102	biological_process	positive regulation of T cell proliferation
D	0042104	biological_process	positive regulation of activated T cell proliferation
D	0043066	biological_process	negative regulation of apoptotic process
D	0043208	molecular_function	glycosphingolipid binding
D	0045471	biological_process	response to ethanol
D	0045582	biological_process	positive regulation of T cell differentiation
D	0045591	biological_process	positive regulation of regulatory T cell differentiation
D	0045621	biological_process	positive regulation of lymphocyte differentiation
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046013	biological_process	regulation of T cell homeostatic proliferation
D	0046651	biological_process	lymphocyte proliferation
D	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
D	0050672	biological_process	negative regulation of lymphocyte proliferation
D	0050728	biological_process	negative regulation of inflammatory response
D	0050729	biological_process	positive regulation of inflammatory response
D	0050798	biological_process	activated T cell proliferation
D	0060999	biological_process	positive regulation of dendritic spine development
D	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
D	0097696	biological_process	cell surface receptor signaling pathway via STAT
D	1900100	biological_process	positive regulation of plasma cell differentiation
D	1901327	biological_process	response to tacrolimus
D	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
D	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
E	0004896	molecular_function	cytokine receptor activity
E	0016020	cellular_component	membrane
F	0004896	molecular_function	cytokine receptor activity
F	0016020	cellular_component	membrane
G	0002250	biological_process	adaptive immune response
G	0002366	biological_process	leukocyte activation involved in immune response
G	0002376	biological_process	immune system process
G	0002639	biological_process	positive regulation of immunoglobulin production
G	0002903	biological_process	negative regulation of B cell apoptotic process
G	0005125	molecular_function	cytokine activity
G	0005134	molecular_function	interleukin-2 receptor binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0006366	biological_process	transcription by RNA polymerase II
G	0006955	biological_process	immune response
G	0007155	biological_process	cell adhesion
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
G	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
G	0007267	biological_process	cell-cell signaling
G	0008083	molecular_function	growth factor activity
G	0008284	biological_process	positive regulation of cell population proliferation
G	0010467	biological_process	gene expression
G	0019209	molecular_function	kinase activator activity
G	0030101	biological_process	natural killer cell activation
G	0030217	biological_process	T cell differentiation
G	0030246	molecular_function	carbohydrate binding
G	0030307	biological_process	positive regulation of cell growth
G	0030890	biological_process	positive regulation of B cell proliferation
G	0031851	molecular_function	kappa-type opioid receptor binding
G	0032729	biological_process	positive regulation of type II interferon production
G	0032740	biological_process	positive regulation of interleukin-17 production
G	0034105	biological_process	positive regulation of tissue remodeling
G	0038110	biological_process	interleukin-2-mediated signaling pathway
G	0042098	biological_process	T cell proliferation
G	0042102	biological_process	positive regulation of T cell proliferation
G	0042104	biological_process	positive regulation of activated T cell proliferation
G	0043066	biological_process	negative regulation of apoptotic process
G	0043208	molecular_function	glycosphingolipid binding
G	0045471	biological_process	response to ethanol
G	0045582	biological_process	positive regulation of T cell differentiation
G	0045591	biological_process	positive regulation of regulatory T cell differentiation
G	0045621	biological_process	positive regulation of lymphocyte differentiation
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046013	biological_process	regulation of T cell homeostatic proliferation
G	0046651	biological_process	lymphocyte proliferation
G	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
G	0050672	biological_process	negative regulation of lymphocyte proliferation
G	0050728	biological_process	negative regulation of inflammatory response
G	0050729	biological_process	positive regulation of inflammatory response
G	0050798	biological_process	activated T cell proliferation
G	0060999	biological_process	positive regulation of dendritic spine development
G	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
G	0097696	biological_process	cell surface receptor signaling pathway via STAT
G	1900100	biological_process	positive regulation of plasma cell differentiation
G	1901327	biological_process	response to tacrolimus
G	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
G	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
H	0004896	molecular_function	cytokine receptor activity
H	0016020	cellular_component	membrane
I	0004896	molecular_function	cytokine receptor activity
I	0016020	cellular_component	membrane
J	0002250	biological_process	adaptive immune response
J	0002366	biological_process	leukocyte activation involved in immune response
J	0002376	biological_process	immune system process
J	0002639	biological_process	positive regulation of immunoglobulin production
J	0002903	biological_process	negative regulation of B cell apoptotic process
J	0005125	molecular_function	cytokine activity
J	0005134	molecular_function	interleukin-2 receptor binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0006366	biological_process	transcription by RNA polymerase II
J	0006955	biological_process	immune response
J	0007155	biological_process	cell adhesion
J	0007186	biological_process	G protein-coupled receptor signaling pathway
J	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
J	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
J	0007267	biological_process	cell-cell signaling
J	0008083	molecular_function	growth factor activity
J	0008284	biological_process	positive regulation of cell population proliferation
J	0010467	biological_process	gene expression
J	0019209	molecular_function	kinase activator activity
J	0030101	biological_process	natural killer cell activation
J	0030217	biological_process	T cell differentiation
J	0030246	molecular_function	carbohydrate binding
J	0030307	biological_process	positive regulation of cell growth
J	0030890	biological_process	positive regulation of B cell proliferation
J	0031851	molecular_function	kappa-type opioid receptor binding
J	0032729	biological_process	positive regulation of type II interferon production
J	0032740	biological_process	positive regulation of interleukin-17 production
J	0034105	biological_process	positive regulation of tissue remodeling
J	0038110	biological_process	interleukin-2-mediated signaling pathway
J	0042098	biological_process	T cell proliferation
J	0042102	biological_process	positive regulation of T cell proliferation
J	0042104	biological_process	positive regulation of activated T cell proliferation
J	0043066	biological_process	negative regulation of apoptotic process
J	0043208	molecular_function	glycosphingolipid binding
J	0045471	biological_process	response to ethanol
J	0045582	biological_process	positive regulation of T cell differentiation
J	0045591	biological_process	positive regulation of regulatory T cell differentiation
J	0045621	biological_process	positive regulation of lymphocyte differentiation
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0046013	biological_process	regulation of T cell homeostatic proliferation
J	0046651	biological_process	lymphocyte proliferation
J	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
J	0050672	biological_process	negative regulation of lymphocyte proliferation
J	0050728	biological_process	negative regulation of inflammatory response
J	0050729	biological_process	positive regulation of inflammatory response
J	0050798	biological_process	activated T cell proliferation
J	0060999	biological_process	positive regulation of dendritic spine development
J	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
J	0097696	biological_process	cell surface receptor signaling pathway via STAT
J	1900100	biological_process	positive regulation of plasma cell differentiation
J	1901327	biological_process	response to tacrolimus
J	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
J	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
K	0004896	molecular_function	cytokine receptor activity
K	0016020	cellular_component	membrane
L	0004896	molecular_function	cytokine receptor activity
L	0016020	cellular_component	membrane
M	0002250	biological_process	adaptive immune response
M	0002366	biological_process	leukocyte activation involved in immune response
M	0002376	biological_process	immune system process
M	0002639	biological_process	positive regulation of immunoglobulin production
M	0002903	biological_process	negative regulation of B cell apoptotic process
M	0005125	molecular_function	cytokine activity
M	0005134	molecular_function	interleukin-2 receptor binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0006366	biological_process	transcription by RNA polymerase II
M	0006955	biological_process	immune response
M	0007155	biological_process	cell adhesion
M	0007186	biological_process	G protein-coupled receptor signaling pathway
M	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
M	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
M	0007267	biological_process	cell-cell signaling
M	0008083	molecular_function	growth factor activity
M	0008284	biological_process	positive regulation of cell population proliferation
M	0010467	biological_process	gene expression
M	0019209	molecular_function	kinase activator activity
M	0030101	biological_process	natural killer cell activation
M	0030217	biological_process	T cell differentiation
M	0030246	molecular_function	carbohydrate binding
M	0030307	biological_process	positive regulation of cell growth
M	0030890	biological_process	positive regulation of B cell proliferation
M	0031851	molecular_function	kappa-type opioid receptor binding
M	0032729	biological_process	positive regulation of type II interferon production
M	0032740	biological_process	positive regulation of interleukin-17 production
M	0034105	biological_process	positive regulation of tissue remodeling
M	0038110	biological_process	interleukin-2-mediated signaling pathway
M	0042098	biological_process	T cell proliferation
M	0042102	biological_process	positive regulation of T cell proliferation
M	0042104	biological_process	positive regulation of activated T cell proliferation
M	0043066	biological_process	negative regulation of apoptotic process
M	0043208	molecular_function	glycosphingolipid binding
M	0045471	biological_process	response to ethanol
M	0045582	biological_process	positive regulation of T cell differentiation
M	0045591	biological_process	positive regulation of regulatory T cell differentiation
M	0045621	biological_process	positive regulation of lymphocyte differentiation
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	0046013	biological_process	regulation of T cell homeostatic proliferation
M	0046651	biological_process	lymphocyte proliferation
M	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
M	0050672	biological_process	negative regulation of lymphocyte proliferation
M	0050728	biological_process	negative regulation of inflammatory response
M	0050729	biological_process	positive regulation of inflammatory response
M	0050798	biological_process	activated T cell proliferation
M	0060999	biological_process	positive regulation of dendritic spine development
M	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
M	0097696	biological_process	cell surface receptor signaling pathway via STAT
M	1900100	biological_process	positive regulation of plasma cell differentiation
M	1901327	biological_process	response to tacrolimus
M	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
M	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
N	0004896	molecular_function	cytokine receptor activity
N	0016020	cellular_component	membrane
O	0004896	molecular_function	cytokine receptor activity
O	0016020	cellular_component	membrane
P	0002250	biological_process	adaptive immune response
P	0002366	biological_process	leukocyte activation involved in immune response
P	0002376	biological_process	immune system process
P	0002639	biological_process	positive regulation of immunoglobulin production
P	0002903	biological_process	negative regulation of B cell apoptotic process
P	0005125	molecular_function	cytokine activity
P	0005134	molecular_function	interleukin-2 receptor binding
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0006366	biological_process	transcription by RNA polymerase II
P	0006955	biological_process	immune response
P	0007155	biological_process	cell adhesion
P	0007186	biological_process	G protein-coupled receptor signaling pathway
P	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
P	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
P	0007267	biological_process	cell-cell signaling
P	0008083	molecular_function	growth factor activity
P	0008284	biological_process	positive regulation of cell population proliferation
P	0010467	biological_process	gene expression
P	0019209	molecular_function	kinase activator activity
P	0030101	biological_process	natural killer cell activation
P	0030217	biological_process	T cell differentiation
P	0030246	molecular_function	carbohydrate binding
P	0030307	biological_process	positive regulation of cell growth
P	0030890	biological_process	positive regulation of B cell proliferation
P	0031851	molecular_function	kappa-type opioid receptor binding
P	0032729	biological_process	positive regulation of type II interferon production
P	0032740	biological_process	positive regulation of interleukin-17 production
P	0034105	biological_process	positive regulation of tissue remodeling
P	0038110	biological_process	interleukin-2-mediated signaling pathway
P	0042098	biological_process	T cell proliferation
P	0042102	biological_process	positive regulation of T cell proliferation
P	0042104	biological_process	positive regulation of activated T cell proliferation
P	0043066	biological_process	negative regulation of apoptotic process
P	0043208	molecular_function	glycosphingolipid binding
P	0045471	biological_process	response to ethanol
P	0045582	biological_process	positive regulation of T cell differentiation
P	0045591	biological_process	positive regulation of regulatory T cell differentiation
P	0045621	biological_process	positive regulation of lymphocyte differentiation
P	0045944	biological_process	positive regulation of transcription by RNA polymerase II
P	0046013	biological_process	regulation of T cell homeostatic proliferation
P	0046651	biological_process	lymphocyte proliferation
P	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
P	0050672	biological_process	negative regulation of lymphocyte proliferation
P	0050728	biological_process	negative regulation of inflammatory response
P	0050729	biological_process	positive regulation of inflammatory response
P	0050798	biological_process	activated T cell proliferation
P	0060999	biological_process	positive regulation of dendritic spine development
P	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
P	0097696	biological_process	cell surface receptor signaling pathway via STAT
P	1900100	biological_process	positive regulation of plasma cell differentiation
P	1901327	biological_process	response to tacrolimus
P	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
P	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
Q	0004896	molecular_function	cytokine receptor activity
Q	0016020	cellular_component	membrane
R	0004896	molecular_function	cytokine receptor activity
R	0016020	cellular_component	membrane
S	0002250	biological_process	adaptive immune response
S	0002366	biological_process	leukocyte activation involved in immune response
S	0002376	biological_process	immune system process
S	0002639	biological_process	positive regulation of immunoglobulin production
S	0002903	biological_process	negative regulation of B cell apoptotic process
S	0005125	molecular_function	cytokine activity
S	0005134	molecular_function	interleukin-2 receptor binding
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005615	cellular_component	extracellular space
S	0006366	biological_process	transcription by RNA polymerase II
S	0006955	biological_process	immune response
S	0007155	biological_process	cell adhesion
S	0007186	biological_process	G protein-coupled receptor signaling pathway
S	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
S	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
S	0007267	biological_process	cell-cell signaling
S	0008083	molecular_function	growth factor activity
S	0008284	biological_process	positive regulation of cell population proliferation
S	0010467	biological_process	gene expression
S	0019209	molecular_function	kinase activator activity
S	0030101	biological_process	natural killer cell activation
S	0030217	biological_process	T cell differentiation
S	0030246	molecular_function	carbohydrate binding
S	0030307	biological_process	positive regulation of cell growth
S	0030890	biological_process	positive regulation of B cell proliferation
S	0031851	molecular_function	kappa-type opioid receptor binding
S	0032729	biological_process	positive regulation of type II interferon production
S	0032740	biological_process	positive regulation of interleukin-17 production
S	0034105	biological_process	positive regulation of tissue remodeling
S	0038110	biological_process	interleukin-2-mediated signaling pathway
S	0042098	biological_process	T cell proliferation
S	0042102	biological_process	positive regulation of T cell proliferation
S	0042104	biological_process	positive regulation of activated T cell proliferation
S	0043066	biological_process	negative regulation of apoptotic process
S	0043208	molecular_function	glycosphingolipid binding
S	0045471	biological_process	response to ethanol
S	0045582	biological_process	positive regulation of T cell differentiation
S	0045591	biological_process	positive regulation of regulatory T cell differentiation
S	0045621	biological_process	positive regulation of lymphocyte differentiation
S	0045944	biological_process	positive regulation of transcription by RNA polymerase II
S	0046013	biological_process	regulation of T cell homeostatic proliferation
S	0046651	biological_process	lymphocyte proliferation
S	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
S	0050672	biological_process	negative regulation of lymphocyte proliferation
S	0050728	biological_process	negative regulation of inflammatory response
S	0050729	biological_process	positive regulation of inflammatory response
S	0050798	biological_process	activated T cell proliferation
S	0060999	biological_process	positive regulation of dendritic spine development
S	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
S	0097696	biological_process	cell surface receptor signaling pathway via STAT
S	1900100	biological_process	positive regulation of plasma cell differentiation
S	1901327	biological_process	response to tacrolimus
S	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
S	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
T	0004896	molecular_function	cytokine receptor activity
T	0016020	cellular_component	membrane
U	0004896	molecular_function	cytokine receptor activity
U	0016020	cellular_component	membrane
V	0002250	biological_process	adaptive immune response
V	0002366	biological_process	leukocyte activation involved in immune response
V	0002376	biological_process	immune system process
V	0002639	biological_process	positive regulation of immunoglobulin production
V	0002903	biological_process	negative regulation of B cell apoptotic process
V	0005125	molecular_function	cytokine activity
V	0005134	molecular_function	interleukin-2 receptor binding
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005615	cellular_component	extracellular space
V	0006366	biological_process	transcription by RNA polymerase II
V	0006955	biological_process	immune response
V	0007155	biological_process	cell adhesion
V	0007186	biological_process	G protein-coupled receptor signaling pathway
V	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
V	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
V	0007267	biological_process	cell-cell signaling
V	0008083	molecular_function	growth factor activity
V	0008284	biological_process	positive regulation of cell population proliferation
V	0010467	biological_process	gene expression
V	0019209	molecular_function	kinase activator activity
V	0030101	biological_process	natural killer cell activation
V	0030217	biological_process	T cell differentiation
V	0030246	molecular_function	carbohydrate binding
V	0030307	biological_process	positive regulation of cell growth
V	0030890	biological_process	positive regulation of B cell proliferation
V	0031851	molecular_function	kappa-type opioid receptor binding
V	0032729	biological_process	positive regulation of type II interferon production
V	0032740	biological_process	positive regulation of interleukin-17 production
V	0034105	biological_process	positive regulation of tissue remodeling
V	0038110	biological_process	interleukin-2-mediated signaling pathway
V	0042098	biological_process	T cell proliferation
V	0042102	biological_process	positive regulation of T cell proliferation
V	0042104	biological_process	positive regulation of activated T cell proliferation
V	0043066	biological_process	negative regulation of apoptotic process
V	0043208	molecular_function	glycosphingolipid binding
V	0045471	biological_process	response to ethanol
V	0045582	biological_process	positive regulation of T cell differentiation
V	0045591	biological_process	positive regulation of regulatory T cell differentiation
V	0045621	biological_process	positive regulation of lymphocyte differentiation
V	0045944	biological_process	positive regulation of transcription by RNA polymerase II
V	0046013	biological_process	regulation of T cell homeostatic proliferation
V	0046651	biological_process	lymphocyte proliferation
V	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
V	0050672	biological_process	negative regulation of lymphocyte proliferation
V	0050728	biological_process	negative regulation of inflammatory response
V	0050729	biological_process	positive regulation of inflammatory response
V	0050798	biological_process	activated T cell proliferation
V	0060999	biological_process	positive regulation of dendritic spine development
V	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
V	0097696	biological_process	cell surface receptor signaling pathway via STAT
V	1900100	biological_process	positive regulation of plasma cell differentiation
V	1901327	biological_process	response to tacrolimus
V	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
V	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
W	0004896	molecular_function	cytokine receptor activity
W	0016020	cellular_component	membrane
X	0004896	molecular_function	cytokine receptor activity
X	0016020	cellular_component	membrane
Y	0002250	biological_process	adaptive immune response
Y	0002366	biological_process	leukocyte activation involved in immune response
Y	0002376	biological_process	immune system process
Y	0002639	biological_process	positive regulation of immunoglobulin production
Y	0002903	biological_process	negative regulation of B cell apoptotic process
Y	0005125	molecular_function	cytokine activity
Y	0005134	molecular_function	interleukin-2 receptor binding
Y	0005515	molecular_function	protein binding
Y	0005576	cellular_component	extracellular region
Y	0005615	cellular_component	extracellular space
Y	0006366	biological_process	transcription by RNA polymerase II
Y	0006955	biological_process	immune response
Y	0007155	biological_process	cell adhesion
Y	0007186	biological_process	G protein-coupled receptor signaling pathway
Y	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
Y	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
Y	0007267	biological_process	cell-cell signaling
Y	0008083	molecular_function	growth factor activity
Y	0008284	biological_process	positive regulation of cell population proliferation
Y	0010467	biological_process	gene expression
Y	0019209	molecular_function	kinase activator activity
Y	0030101	biological_process	natural killer cell activation
Y	0030217	biological_process	T cell differentiation
Y	0030246	molecular_function	carbohydrate binding
Y	0030307	biological_process	positive regulation of cell growth
Y	0030890	biological_process	positive regulation of B cell proliferation
Y	0031851	molecular_function	kappa-type opioid receptor binding
Y	0032729	biological_process	positive regulation of type II interferon production
Y	0032740	biological_process	positive regulation of interleukin-17 production
Y	0034105	biological_process	positive regulation of tissue remodeling
Y	0038110	biological_process	interleukin-2-mediated signaling pathway
Y	0042098	biological_process	T cell proliferation
Y	0042102	biological_process	positive regulation of T cell proliferation
Y	0042104	biological_process	positive regulation of activated T cell proliferation
Y	0043066	biological_process	negative regulation of apoptotic process
Y	0043208	molecular_function	glycosphingolipid binding
Y	0045471	biological_process	response to ethanol
Y	0045582	biological_process	positive regulation of T cell differentiation
Y	0045591	biological_process	positive regulation of regulatory T cell differentiation
Y	0045621	biological_process	positive regulation of lymphocyte differentiation
Y	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Y	0046013	biological_process	regulation of T cell homeostatic proliferation
Y	0046651	biological_process	lymphocyte proliferation
Y	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
Y	0050672	biological_process	negative regulation of lymphocyte proliferation
Y	0050728	biological_process	negative regulation of inflammatory response
Y	0050729	biological_process	positive regulation of inflammatory response
Y	0050798	biological_process	activated T cell proliferation
Y	0060999	biological_process	positive regulation of dendritic spine development
Y	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
Y	0097696	biological_process	cell surface receptor signaling pathway via STAT
Y	1900100	biological_process	positive regulation of plasma cell differentiation
Y	1901327	biological_process	response to tacrolimus
Y	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
Y	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
Z	0004896	molecular_function	cytokine receptor activity
Z	0016020	cellular_component	membrane
a	0004896	molecular_function	cytokine receptor activity
a	0016020	cellular_component	membrane
b	0002250	biological_process	adaptive immune response
b	0002366	biological_process	leukocyte activation involved in immune response
b	0002376	biological_process	immune system process
b	0002639	biological_process	positive regulation of immunoglobulin production
b	0002903	biological_process	negative regulation of B cell apoptotic process
b	0005125	molecular_function	cytokine activity
b	0005134	molecular_function	interleukin-2 receptor binding
b	0005515	molecular_function	protein binding
b	0005576	cellular_component	extracellular region
b	0005615	cellular_component	extracellular space
b	0006366	biological_process	transcription by RNA polymerase II
b	0006955	biological_process	immune response
b	0007155	biological_process	cell adhesion
b	0007186	biological_process	G protein-coupled receptor signaling pathway
b	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
b	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
b	0007267	biological_process	cell-cell signaling
b	0008083	molecular_function	growth factor activity
b	0008284	biological_process	positive regulation of cell population proliferation
b	0010467	biological_process	gene expression
b	0019209	molecular_function	kinase activator activity
b	0030101	biological_process	natural killer cell activation
b	0030217	biological_process	T cell differentiation
b	0030246	molecular_function	carbohydrate binding
b	0030307	biological_process	positive regulation of cell growth
b	0030890	biological_process	positive regulation of B cell proliferation
b	0031851	molecular_function	kappa-type opioid receptor binding
b	0032729	biological_process	positive regulation of type II interferon production
b	0032740	biological_process	positive regulation of interleukin-17 production
b	0034105	biological_process	positive regulation of tissue remodeling
b	0038110	biological_process	interleukin-2-mediated signaling pathway
b	0042098	biological_process	T cell proliferation
b	0042102	biological_process	positive regulation of T cell proliferation
b	0042104	biological_process	positive regulation of activated T cell proliferation
b	0043066	biological_process	negative regulation of apoptotic process
b	0043208	molecular_function	glycosphingolipid binding
b	0045471	biological_process	response to ethanol
b	0045582	biological_process	positive regulation of T cell differentiation
b	0045591	biological_process	positive regulation of regulatory T cell differentiation
b	0045621	biological_process	positive regulation of lymphocyte differentiation
b	0045944	biological_process	positive regulation of transcription by RNA polymerase II
b	0046013	biological_process	regulation of T cell homeostatic proliferation
b	0046651	biological_process	lymphocyte proliferation
b	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
b	0050672	biological_process	negative regulation of lymphocyte proliferation
b	0050728	biological_process	negative regulation of inflammatory response
b	0050729	biological_process	positive regulation of inflammatory response
b	0050798	biological_process	activated T cell proliferation
b	0060999	biological_process	positive regulation of dendritic spine development
b	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
b	0097696	biological_process	cell surface receptor signaling pathway via STAT
b	1900100	biological_process	positive regulation of plasma cell differentiation
b	1901327	biological_process	response to tacrolimus
b	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
b	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
c	0004896	molecular_function	cytokine receptor activity
c	0016020	cellular_component	membrane
d	0004896	molecular_function	cytokine receptor activity
d	0016020	cellular_component	membrane
e	0002250	biological_process	adaptive immune response
e	0002366	biological_process	leukocyte activation involved in immune response
e	0002376	biological_process	immune system process
e	0002639	biological_process	positive regulation of immunoglobulin production
e	0002903	biological_process	negative regulation of B cell apoptotic process
e	0005125	molecular_function	cytokine activity
e	0005134	molecular_function	interleukin-2 receptor binding
e	0005515	molecular_function	protein binding
e	0005576	cellular_component	extracellular region
e	0005615	cellular_component	extracellular space
e	0006366	biological_process	transcription by RNA polymerase II
e	0006955	biological_process	immune response
e	0007155	biological_process	cell adhesion
e	0007186	biological_process	G protein-coupled receptor signaling pathway
e	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
e	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
e	0007267	biological_process	cell-cell signaling
e	0008083	molecular_function	growth factor activity
e	0008284	biological_process	positive regulation of cell population proliferation
e	0010467	biological_process	gene expression
e	0019209	molecular_function	kinase activator activity
e	0030101	biological_process	natural killer cell activation
e	0030217	biological_process	T cell differentiation
e	0030246	molecular_function	carbohydrate binding
e	0030307	biological_process	positive regulation of cell growth
e	0030890	biological_process	positive regulation of B cell proliferation
e	0031851	molecular_function	kappa-type opioid receptor binding
e	0032729	biological_process	positive regulation of type II interferon production
e	0032740	biological_process	positive regulation of interleukin-17 production
e	0034105	biological_process	positive regulation of tissue remodeling
e	0038110	biological_process	interleukin-2-mediated signaling pathway
e	0042098	biological_process	T cell proliferation
e	0042102	biological_process	positive regulation of T cell proliferation
e	0042104	biological_process	positive regulation of activated T cell proliferation
e	0043066	biological_process	negative regulation of apoptotic process
e	0043208	molecular_function	glycosphingolipid binding
e	0045471	biological_process	response to ethanol
e	0045582	biological_process	positive regulation of T cell differentiation
e	0045591	biological_process	positive regulation of regulatory T cell differentiation
e	0045621	biological_process	positive regulation of lymphocyte differentiation
e	0045944	biological_process	positive regulation of transcription by RNA polymerase II
e	0046013	biological_process	regulation of T cell homeostatic proliferation
e	0046651	biological_process	lymphocyte proliferation
e	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
e	0050672	biological_process	negative regulation of lymphocyte proliferation
e	0050728	biological_process	negative regulation of inflammatory response
e	0050729	biological_process	positive regulation of inflammatory response
e	0050798	biological_process	activated T cell proliferation
e	0060999	biological_process	positive regulation of dendritic spine development
e	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
e	0097696	biological_process	cell surface receptor signaling pathway via STAT
e	1900100	biological_process	positive regulation of plasma cell differentiation
e	1901327	biological_process	response to tacrolimus
e	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
e	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
f	0004896	molecular_function	cytokine receptor activity
f	0016020	cellular_component	membrane
g	0004896	molecular_function	cytokine receptor activity
g	0016020	cellular_component	membrane
h	0002250	biological_process	adaptive immune response
h	0002366	biological_process	leukocyte activation involved in immune response
h	0002376	biological_process	immune system process
h	0002639	biological_process	positive regulation of immunoglobulin production
h	0002903	biological_process	negative regulation of B cell apoptotic process
h	0005125	molecular_function	cytokine activity
h	0005134	molecular_function	interleukin-2 receptor binding
h	0005515	molecular_function	protein binding
h	0005576	cellular_component	extracellular region
h	0005615	cellular_component	extracellular space
h	0006366	biological_process	transcription by RNA polymerase II
h	0006955	biological_process	immune response
h	0007155	biological_process	cell adhesion
h	0007186	biological_process	G protein-coupled receptor signaling pathway
h	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
h	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
h	0007267	biological_process	cell-cell signaling
h	0008083	molecular_function	growth factor activity
h	0008284	biological_process	positive regulation of cell population proliferation
h	0010467	biological_process	gene expression
h	0019209	molecular_function	kinase activator activity
h	0030101	biological_process	natural killer cell activation
h	0030217	biological_process	T cell differentiation
h	0030246	molecular_function	carbohydrate binding
h	0030307	biological_process	positive regulation of cell growth
h	0030890	biological_process	positive regulation of B cell proliferation
h	0031851	molecular_function	kappa-type opioid receptor binding
h	0032729	biological_process	positive regulation of type II interferon production
h	0032740	biological_process	positive regulation of interleukin-17 production
h	0034105	biological_process	positive regulation of tissue remodeling
h	0038110	biological_process	interleukin-2-mediated signaling pathway
h	0042098	biological_process	T cell proliferation
h	0042102	biological_process	positive regulation of T cell proliferation
h	0042104	biological_process	positive regulation of activated T cell proliferation
h	0043066	biological_process	negative regulation of apoptotic process
h	0043208	molecular_function	glycosphingolipid binding
h	0045471	biological_process	response to ethanol
h	0045582	biological_process	positive regulation of T cell differentiation
h	0045591	biological_process	positive regulation of regulatory T cell differentiation
h	0045621	biological_process	positive regulation of lymphocyte differentiation
h	0045944	biological_process	positive regulation of transcription by RNA polymerase II
h	0046013	biological_process	regulation of T cell homeostatic proliferation
h	0046651	biological_process	lymphocyte proliferation
h	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
h	0050672	biological_process	negative regulation of lymphocyte proliferation
h	0050728	biological_process	negative regulation of inflammatory response
h	0050729	biological_process	positive regulation of inflammatory response
h	0050798	biological_process	activated T cell proliferation
h	0060999	biological_process	positive regulation of dendritic spine development
h	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
h	0097696	biological_process	cell surface receptor signaling pathway via STAT
h	1900100	biological_process	positive regulation of plasma cell differentiation
h	1901327	biological_process	response to tacrolimus
h	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
h	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
i	0004896	molecular_function	cytokine receptor activity
i	0016020	cellular_component	membrane
j	0004896	molecular_function	cytokine receptor activity
j	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00424
Number of Residues	13
Details	INTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL

Chain	Residue	Details
A	THR51-LEU63

---

site_id	PS01355
Number of Residues	32
Details	HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. LtpdtqyefqVRvkplqgeftt..........WSpWSqplaF

Chain	Residue	Details
B	LEU172-PHE203
a	VAL191-TRP224

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16477002","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16293754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16477002","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---