3Q2S

Crystal Structure of CFIm68 RRM/CFIm25 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cleavage and polyadenylation specificity factor subunit 5	polymer	207	24030.7	2	UniProt (O43809) Pfam (PF13869)	Homo sapiens (human)	Cleavage and polyadenylation specificity factor 25 kDa subunit, CPSF 25 kDa subunit, Nucleoside diphosphate-linked moiety X motif 21, Nudix motif 21, Pre-mRNA cleavage factor Im 25 kDa subunit
2	C, D (C, D)	Cleavage and polyadenylation specificity factor subunit 6	polymer	229	24485.9	2	UniProt (Q16630) Pfam (PF00076)	Homo sapiens (human)	Cleavage and polyadenylation specificity factor 68 kDa subunit, CPSF 68 kDa subunit, Pre-mRNA cleavage factor Im 68 kDa subunit, Protein HPBRII-4/7
3	E, F, G, H (A, B, C, D)	water	water		18.0	20	Chemie (HOH)

Sequence modifications

C, D: 13 - 235 (UniProt: Q16630)

PDB	External Database	Details
Val 159	Cys 159	engineered mutation
His 236	-	expression tag
His 237	-	expression tag
His 238	-	expression tag
His 239	-	expression tag
His 240	-	expression tag
His 241	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	97033.1
All*	Total formula weight	97033.1

*Water molecules are not included.