3Q2S

Crystal Structure of CFIm68 RRM/CFIm25 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003682	molecular_function	chromatin binding
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005847	cellular_component	mRNA cleavage and polyadenylation specificity factor complex
A	0005849	cellular_component	mRNA cleavage factor complex
A	0006397	biological_process	mRNA processing
A	0010608	biological_process	post-transcriptional regulation of gene expression
A	0016604	cellular_component	nuclear body
A	0030154	biological_process	cell differentiation
A	0031124	biological_process	mRNA 3'-end processing
A	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
A	0042382	cellular_component	paraspeckles
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0042826	molecular_function	histone deacetylase binding
A	0051262	biological_process	protein tetramerization
A	0051290	biological_process	protein heterotetramerization
A	0110104	biological_process	mRNA alternative polyadenylation
A	0180010	biological_process	co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
A	1900365	biological_process	obsolete positive regulation of mRNA polyadenylation
A	2000738	biological_process	positive regulation of stem cell differentiation
A	2000975	biological_process	positive regulation of pro-B cell differentiation
B	0003682	molecular_function	chromatin binding
B	0003723	molecular_function	RNA binding
B	0003729	molecular_function	mRNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005847	cellular_component	mRNA cleavage and polyadenylation specificity factor complex
B	0005849	cellular_component	mRNA cleavage factor complex
B	0006397	biological_process	mRNA processing
B	0010608	biological_process	post-transcriptional regulation of gene expression
B	0016604	cellular_component	nuclear body
B	0030154	biological_process	cell differentiation
B	0031124	biological_process	mRNA 3'-end processing
B	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
B	0042382	cellular_component	paraspeckles
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042826	molecular_function	histone deacetylase binding
B	0051262	biological_process	protein tetramerization
B	0051290	biological_process	protein heterotetramerization
B	0110104	biological_process	mRNA alternative polyadenylation
B	0180010	biological_process	co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
B	1900365	biological_process	obsolete positive regulation of mRNA polyadenylation
B	2000738	biological_process	positive regulation of stem cell differentiation
B	2000975	biological_process	positive regulation of pro-B cell differentiation
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	125
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	79
Details	Region: {"description":"Necessary for interactions with PAPOLA and PABPN1","evidences":[{"source":"PubMed","id":"15169763","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"Interaction with RNA","evidences":[{"source":"PubMed","id":"20479262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21295486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MDG","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3MDI","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3Q2T","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	42
Details	Motif: {"description":"Nudix box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Interaction with RNA","evidences":[{"source":"PubMed","id":"20479262","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MDG","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3MDI","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17172643","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	160
Details	Domain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI10
Number of Residues	160
Details	Region: {"description":"Necessary for nuclear paraspeckles localization","evidences":[{"source":"PubMed","id":"17267687","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"30916345","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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