3PHB

Crystal Structure of human purine nucleoside phosphorylase in complex with DADMe-ImmG

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (E, Q, S, T, U...)	Purine nucleoside phosphorylase	polymer	324	36148.2	6	UniProt (P00491) Pfam (PF01048)	Homo sapiens (human)	PNP, Inosine phosphorylase
2	G, J, N, Q, S... (E, Q, S, T, U...)	2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one	non-polymer		279.3	6	Chemie (IM5)
3	H, I, K, L, M... (E, Q, S, T, U...)	PHOSPHATE ION	non-polymer		95.0	12	Chemie (PO4)
4	AA, BA, CA, DA, Y... (S, T, U, Y, E...)	water	water		18.0	90	Chemie (HOH)

Sequence modifications

E, Q, S, T, U, Y: 1 - 289 (UniProt: P00491)

PDB	External Database	Details
Met -34	-	expression tag
Arg -33	-	expression tag
Gly -32	-	expression tag
Ser -31	-	expression tag
His -30	-	expression tag
His -29	-	expression tag
His -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
Gly -24	-	expression tag
Met -23	-	expression tag
Ala -22	-	expression tag
Ser -21	-	expression tag
Met -20	-	expression tag
Thr -19	-	expression tag
Gly -18	-	expression tag
Gly -17	-	expression tag
Gln -16	-	expression tag
Gln -15	-	expression tag
Met -14	-	expression tag
Gly -13	-	expression tag
Arg -12	-	expression tag
Asp -11	-	expression tag
Leu -10	-	expression tag
Tyr -9	-	expression tag
Asp -8	-	expression tag
Asp -7	-	expression tag
Asp -6	-	expression tag
Asp -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Pro -2	-	expression tag
Thr -1	-	expression tag
Leu 0	-	expression tag
Ser 51	Gly 51	conflict

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	216889.0
Non-Polymers*	Number of molecules	18
	Total formula weight	2815.4
All*	Total formula weight	219704.4

*Water molecules are not included.