3P7O
Rat Insulin Degrading Enzyme (Insulysin) E111F mutant with two bound peptides
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin-degrading enzyme | polymer | 1019 | 117882.9 | 1 | UniProt (P35559) Pfam (PF00675) Pfam (PF05193) Pfam (PF16187) Pfam (PF22456) | Rattus norvegicus (brown rat rat rats) | Insulin protease, Insulinase, Insulysin |
| 2 | B (B) | active site bound peptide | polymer | 8 | 698.9 | 1 | Rattus norvegicus (brown rat rat rats) | ||
| 3 | C (C) | distal site bound peptide | polymer | 7 | 613.7 | 1 | Rattus norvegicus (brown rat rat rats) | ||
| 4 | D (A) | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
A: 1 - 1019 (UniProt: P35559)
| PDB | External Database | Details |
|---|---|---|
| Phe 111 | Glu 111 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 119195.5 | |
| All* | Total formula weight | 119195.5 |
