3OY4
Crystal Structure of HIV-1 L76V Protease in Complex with the Protease Inhibitor Darunavir.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HIV-1 PROTEASE | polymer | 99 | 10801.8 | 2 | UniProt (P03369) Pfam (PF00077) | Human immunodeficiency virus type 1 (HIV-1) | Retropepsin, PR |
| 2 | C, D, H, I (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 3 | E, F, G, J, K... (A, B) | ACETATE ION | non-polymer | 59.0 | 7 | Chemie (ACT) | |||
| 4 | N (B) | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) | |||
| 5 | O, P (A, B) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 497 | engineered mutation |
| Ile 64 | Val 554 | conflict |
| Val 76 | Leu 566 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21603.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1340.9 | |
| All* | Total formula weight | 22944.4 |
