Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 100 |
| Chain | Residue |
| A | PRO1 |
| A | LYS55 |
| B | GLY68 |
| B | HIS69 |
| B | LYS70 |
| B | HOH178 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 101 |
| Chain | Residue |
| B | ARG87 |
| A | LYS7 |
| A | ARG8 |
| A | HOH153 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 102 |
| Chain | Residue |
| B | PRO1 |
| B | HIS69 |
| B | HOH176 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 103 |
| Chain | Residue |
| A | GLY73 |
| A | THR74 |
| A | ASN88 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 104 |
| Chain | Residue |
| A | THR91 |
| A | GLN92 |
| A | HOH111 |
| B | GLY49 |
| B | PHE53 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 100 |
| Chain | Residue |
| A | GLY16 |
| A | HOH131 |
| A | HOH164 |
| B | ARG14 |
| B | GLY16 |
| B | GLY17 |
| B | HOH130 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 B 101 |
| Chain | Residue |
| B | LYS20 |
| B | GLU21 |
| B | HOH165 |
| B | HOH167 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 102 |
| Chain | Residue |
| A | PRO39 |
| A | GLY40 |
| B | MET36 |
| B | ASN37 |
| B | HOH175 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT B 103 |
| Chain | Residue |
| B | LYS7 |
| B | ARG8 |
| B | HOH118 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT B 104 |
| Chain | Residue |
| A | PRO63 |
| B | ARG14 |
| B | GLY17 |
| B | LEU19 |
| B | PRO44 |
| B | HOH169 |
| B | HOH172 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT B 105 |
| site_id | BC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 017 B 200 |
| Chain | Residue |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP30 |
| A | VAL32 |
| A | GLY48 |
| A | GLY49 |
| A | VAL82 |
| A | ILE84 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | ASP30 |
| B | GLY48 |
| B | GLY49 |
| B | ILE50 |
| B | HOH111 |
| B | HOH125 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL |
| Chain | Residue | Details |
| A | ALA22-LEU33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
