3ONI
Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor JQ1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Bromodomain containing 2, isoform CRA_a | polymer | 114 | 13375.4 | 1 | UniProt (Q658Y7) Pfam (PF00439) UniProt (by SIFTS) (P25440) In PDB | Homo sapiens (human) | Putative uncharacterized protein DKFZp313H139 |
| 2 | A | (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium | non-polymer | 458.0 | 1 | Chemie (JQ1) | |||
| 3 | A | NICKEL (II) ION | non-polymer | 58.7 | 2 | Chemie (NI) | |||
| 4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | water | water | 18.0 | 174 | Chemie (HOH) |
Sequence modifications
A: 344 - 455 (UniProt: Q658Y7)
| PDB | External Database | Details |
|---|---|---|
| Ser 342 | - | expression tag |
| Met 343 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13375.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 699.5 | |
| All* | Total formula weight | 14074.9 |
