3ONI
Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor JQ1
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE JQ1 A 1 |
Chain | Residue |
A | HOH4 |
A | HOH146 |
A | TRP370 |
A | PRO371 |
A | VAL376 |
A | ASN429 |
A | HIS433 |
A | VAL435 |
site_id | AC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE NI A 456 |
Chain | Residue |
A | ARG419 |
A | ARG419 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NI A 2 |
Chain | Residue |
A | HOH131 |
A | LYS364 |
A | TYR368 |
A | ARG406 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 457 |
Chain | Residue |
A | HOH38 |
A | TYR368 |
A | LYS402 |
A | ASP407 |
A | LYS441 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 458 |
Chain | Residue |
A | HOH91 |
A | TYR426 |
A | ARG440 |
A | GLN443 |
A | GLN443 |
A | ASP444 |
A | GLU447 |
Functional Information from PROSITE/UniProt
site_id | PS00633 |
Number of Residues | 60 |
Details | BROMODOMAIN_1 Bromodomain signature. AwpFykpvDasalglhDYHdiIkhpMdlstVkrkmenrd..Yrdaqefaadvrl.MfsNCykY |
Chain | Residue | Details |
A | ALA369-TYR428 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | VAL418 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | MET421 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | CYS425 |