3OJM
Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Heparin-binding growth factor 1 | polymer | 155 | 17482.7 | 1 | UniProt (P05230) Pfam (PF00167) | Homo sapiens (human) | HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF-beta |
| 2 | B (B) | Fibroblast growth factor receptor 2 | polymer | 231 | 25961.3 | 1 | UniProt (P21802) Pfam (PF07679) Pfam (PF13927) | Homo sapiens (human) | FGFR-2, Keratinocyte growth factor receptor, K-sam |
| 3 | C, D, E (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence modifications
B: 140 - 313 (UniProt: P21802)
| PDB | External Database | Details |
|---|---|---|
| Met 139 | - | initiating methionine |
| Arg 253 | Pro 253 | engineered mutation |
| His 314 | - | SEE REMARK 999 |
| Ser 315 | - | SEE REMARK 999 |
| Gly 316 | - | SEE REMARK 999 |
| Ile 317 | - | SEE REMARK 999 |
| Asn 318 | - | SEE REMARK 999 |
| Ser 319 | - | SEE REMARK 999 |
| Ser 320 | - | SEE REMARK 999 |
| Asn 321 | - | SEE REMARK 999 |
| Ala 322 | - | SEE REMARK 999 |
| Glu 323 | - | SEE REMARK 999 |
| Val 324 | - | SEE REMARK 999 |
| Leu 325 | - | SEE REMARK 999 |
| Ala 326 | - | SEE REMARK 999 |
| Leu 327 | - | SEE REMARK 999 |
| Phe 328 | - | SEE REMARK 999 |
| Asn 329 | - | SEE REMARK 999 |
| Val 330 | - | SEE REMARK 999 |
| Thr 331 | - | SEE REMARK 999 |
| Glu 332 | - | SEE REMARK 999 |
| Ala 333 | - | SEE REMARK 999 |
| Asp 334 | - | SEE REMARK 999 |
| Ala 335 | - | SEE REMARK 999 |
| Gly 336 | - | SEE REMARK 999 |
| Glu 337 | - | SEE REMARK 999 |
| Tyr 338 | - | SEE REMARK 999 |
| Ile 339 | - | SEE REMARK 999 |
| Cys 340 | - | SEE REMARK 999 |
| Lys 341 | - | SEE REMARK 999 |
| Val 342 | - | SEE REMARK 999 |
| Ser 343 | - | SEE REMARK 999 |
| Asn 344 | - | SEE REMARK 999 |
| Tyr 345 | - | SEE REMARK 999 |
| Ile 346 | - | SEE REMARK 999 |
| Gly 347 | - | SEE REMARK 999 |
| Gln 348 | - | SEE REMARK 999 |
| Ala 349 | - | SEE REMARK 999 |
| Asn 350 | - | SEE REMARK 999 |
| Gln 351 | - | SEE REMARK 999 |
| Ser 352 | - | SEE REMARK 999 |
| Ala 353 | - | SEE REMARK 999 |
| Trp 354 | - | SEE REMARK 999 |
| Leu 355 | - | SEE REMARK 999 |
| Thr 356 | - | SEE REMARK 999 |
| Val 357 | - | SEE REMARK 999 |
| Leu 358 | - | SEE REMARK 999 |
| Pro 359 | - | SEE REMARK 999 |
| Lys 360 | - | SEE REMARK 999 |
| Gln 361 | - | SEE REMARK 999 |
| Gln 362 | - | SEE REMARK 999 |
| Ala 363 | - | SEE REMARK 999 |
| Pro 364 | - | SEE REMARK 999 |
| Gly 365 | - | SEE REMARK 999 |
| Arg 366 | - | SEE REMARK 999 |
| Glu 367 | - | SEE REMARK 999 |
| Lys 368 | - | SEE REMARK 999 |
| Glu 369 | - | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43444.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 288.2 | |
| All* | Total formula weight | 43732.2 |
