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3OJM

Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001759biological_processorgan induction
A0005104molecular_functionfibroblast growth factor receptor binding
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0008083molecular_functiongrowth factor activity
A0008201molecular_functionheparin binding
A0008284biological_processpositive regulation of cell population proliferation
A0008543biological_processfibroblast growth factor receptor signaling pathway
A0009653biological_processanatomical structure morphogenesis
A0009887biological_processanimal organ morphogenesis
A0010595biological_processpositive regulation of endothelial cell migration
A0010628biological_processpositive regulation of gene expression
A0030154biological_processcell differentiation
A0030324biological_processlung development
A0030334biological_processregulation of cell migration
A0030335biological_processpositive regulation of cell migration
A0030544molecular_functionHsp70 protein binding
A0031012cellular_componentextracellular matrix
A0032148biological_processactivation of protein kinase B activity
A0034605biological_processcellular response to heat
A0042060biological_processwound healing
A0043406biological_processpositive regulation of MAP kinase activity
A0044548molecular_functionS100 protein binding
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0045766biological_processpositive regulation of angiogenesis
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050673biological_processepithelial cell proliferation
A0050679biological_processpositive regulation of epithelial cell proliferation
A0051781biological_processpositive regulation of cell division
A0060681biological_processbranch elongation involved in ureteric bud branching
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0072163biological_processmesonephric epithelium development
A1901509biological_processregulation of endothelial tube morphogenesis
A1902533biological_processpositive regulation of intracellular signal transduction
A1903672biological_processpositive regulation of sprouting angiogenesis
A2000347biological_processpositive regulation of hepatocyte proliferation
A2000544biological_processregulation of endothelial cell chemotaxis to fibroblast growth factor
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 300
ChainResidue
ALYS127
ALYS133
AARG137
AHOH459

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 301
ChainResidue
AASN33
ALYS127
ALYS128
ALYS133
AHOH456

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 370
ChainResidue
AARG39
AHOH433
BGLN259
BLYS279

Functional Information from PROSITE/UniProt
site_idPS00247
Number of Residues24
DetailsHBGF_FGF HBGF/FGF family signature. GlLyGsqtpne.EClFlErleenhY
ChainResidueDetails
AGLY86-TYR109

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN228
BASN241
BASN265
BASN297
BASN318
BTHR331

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P03968
ChainResidueDetails
AALA2

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PDB entries from 2024-10-30

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