3OG8

Crystal structure of human RIG-I CTD bound to a 14-bp blunt-ended dsRNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Antiviral innate immune response receptor RIG-I	polymer	128	15046.5	2	UniProt (O95786) Pfam (PF11648)	Homo sapiens (human)	ATP-dependent RNA helicase DDX58,DEAD box protein 58,RIG-I-like receptor 1,RLR-1,RNA sensor RIG-I,Retinoic acid-inducible gene 1 protein,RIG-1,Retinoic acid-inducible gene I protein,RIG-I
2	C, D (C, D)	RNA (5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3')	polymer	14	4507.8	2		Synthetic construct
3	E, F (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	G, H, I, J (A, B, C, D)	water	water		18.0	133	Chemie (HOH)

Sequence modifications

A, B: 802 - 925 (UniProt: O95786)

PDB	External Database	Details
Met 801	-	initiating methionine
Ser 829	Cys 829	engineered mutation
Leu 926	-	expression tag
Glu 927	-	expression tag
His 928	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	39108.5
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	39239.3

*Water molecules are not included.