3OG6
The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P212121
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interleukin-29 | polymer | 196 | 22000.0 | 1 | UniProt (Q8IU54) Pfam (PF15177) | Homo sapiens (human) | IL-29, Interferon lambda-1, IFN-lambda-1, Cytokine Zcyto21 |
| 2 | B (B) | Interleukin 28 receptor, alpha (Interferon, lambda receptor) | polymer | 226 | 25320.8 | 1 | UniProt (Q5VTX7) Pfam (PF01108) UniProt (by SIFTS) (Q8IU57) | Homo sapiens (human) | Interleukin 28 receptor, alpha (Interferon, lambda receptor), isoform CRA_e |
| 3 | C (C) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | D, E, H, I (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | F, G (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 266 | Chemie (HOH) |
Sequence modifications
A: 1 - 181 (UniProt: Q8IU54)
B: -1 - 206 (UniProt: Q5VTX7)
| PDB | External Database | Details |
|---|---|---|
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| Asp -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Lys -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Asp 1 | Gly 20 | engineered mutation |
| Pro 10 | Thr 29 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 207 | - | expression tag |
| Ser 208 | - | expression tag |
| Gly 209 | - | expression tag |
| Ser 210 | - | expression tag |
| Ser 211 | - | expression tag |
| Gly 212 | - | expression tag |
| Gly 213 | - | expression tag |
| Ser 214 | - | expression tag |
| Ser 215 | - | expression tag |
| Gly 216 | - | expression tag |
| Thr 217 | - | expression tag |
| Ser 218 | - | expression tag |
| His 219 | - | expression tag |
| His 220 | - | expression tag |
| His 221 | - | expression tag |
| His 222 | - | expression tag |
| His 223 | - | expression tag |
| His 224 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47320.8 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 810.8 | |
| All* | Total formula weight | 48718.1 |
