3OG6

The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P212121

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Interleukin-29	polymer	196	22000.0	1	UniProt (Q8IU54) Pfam (PF15177) In PDB	Homo sapiens (human)	IL-29, Interferon lambda-1, IFN-lambda-1, Cytokine Zcyto21
2	B	Interleukin 28 receptor, alpha (Interferon, lambda receptor)	polymer	226	25320.8	1	UniProt (Q5VTX7) Pfam (PF01108) UniProt (by SIFTS) (Q8IU57) In PDB	Homo sapiens (human)	Interleukin 28 receptor, alpha (Interferon, lambda receptor), isoform CRA_e
3	C	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
4	A, B	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
5	B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
6		water	water		18.0	266	Chemie (HOH)

Sequence modifications

A: 1 - 181 (UniProt: Q8IU54)

PDB	External Database	Details
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Lys -1	-	expression tag
Ala 0	-	expression tag
Asp 1	Gly 20	engineered mutation
Pro 10	Thr 29	engineered mutation

B: -1 - 206 (UniProt: Q5VTX7)

PDB	External Database	Details
Ala 207	-	expression tag
Ser 208	-	expression tag
Gly 209	-	expression tag
Ser 210	-	expression tag
Ser 211	-	expression tag
Gly 212	-	expression tag
Gly 213	-	expression tag
Ser 214	-	expression tag
Ser 215	-	expression tag
Gly 216	-	expression tag
Thr 217	-	expression tag
Ser 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47320.8
Branched	Number of molecules	1
	Total formula weight	586.5
Non-Polymers*	Number of molecules	6
	Total formula weight	810.8
All*	Total formula weight	48718.1

*Water molecules are not included.