3OG4

The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P21212

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Interleukin-29	polymer	178	19795.8	1	UniProt (Q8IU54) Pfam (PF15177)	Homo sapiens (human)	IL-29, Interferon lambda-1, IFN-lambda-1, Cytokine Zcyto21
2	B (B)	Interleukin 28 receptor, alpha (Interferon, lambda receptor)	polymer	226	25320.8	1	UniProt (Q5VTX7) Pfam (PF01108) UniProt (by SIFTS) (Q8IU57)	Homo sapiens (human)	Interleukin 28 receptor, alpha (Interferon, lambda receptor), isoform CRA_e
3	C (C)	beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G44266EX)
4	D (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
5	E, F (A, B)	water	water		18.0	150	Chemie (HOH)

Sequence modifications

B: 1 - 208 (UniProt: Q5VTX7)

PDB	External Database	Details
Ala 209	-	expression tag
Ser 210	-	expression tag
Gly 211	-	expression tag
Ser 212	-	expression tag
Ser 213	-	expression tag
Gly 214	-	expression tag
Gly 215	-	expression tag
Ser 216	-	expression tag
Ser 217	-	expression tag
Gly 218	-	expression tag
Thr 219	-	expression tag
Ser 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag
His 226	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	45116.5
Branched	Number of molecules	1
	Total formula weight	586.5
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	45924.3

*Water molecules are not included.