3NGB
Crystal structure of broadly and potently neutralizing antibody VRC01 in complex with HIV-1 gp120
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J (G, A, D, I) | Envelope glycoprotein gp160 | polymer | 353 | 39211.4 | 4 | UniProt (Q0ED31) Pfam (PF00516) | Human immunodeficiency virus 1 | |
| 2 | B, E, H, K (H, B, E, J) | Antigen binding fragment of heavy chain: Antibody VRC01 | polymer | 224 | 24367.6 | 4 | Homo sapiens | ||
| 3 | C, F, I, L (L, C, F, K) | Antigen binding fragment of light chain: Antibody VRC01 | polymer | 210 | 23172.7 | 4 | Homo sapiens | ||
| 4 | M, N, P (M, N, P) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 5 | O (O) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | AA, AB, BB, CA, CB... (G, D, A, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 46 | Chemie (NAG) | |||
| 7 | BA, CC, LB, MB, QA... (G, J, D, E, A...) | beta-D-glucopyranose | non-polymer | 180.2 | 13 | Chemie (BGC) | |||
| 8 | AC, BC, DC, JB, KB... (I, J, K, D, A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 7 | Chemie (TRS) | |||
| 9 | EC, FC, GC, HC, IC... (G, H, L, A, B...) | water | water | 18.0 | 523 | Chemie (HOH) |
Sequence modifications
G, A, D, I: 44 - 123 (UniProt: Q0ED31)
G, A, D, I: 199 - 301 (UniProt: Q0ED31)
G, A, D, I: 324 - 492 (UniProt: Q0ED31)
G, A, D, I: 199 - 301 (UniProt: Q0ED31)
| PDB | External Database | Details |
|---|---|---|
| Gly 124 | - | linker |
| Gly 198 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 318 | - | linker |
| Gly 319 | - | linker |
| Ser 320 | - | linker |
| Gly 321 | - | linker |
| Ser 322 | - | linker |
| Gly 323 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 347007.0 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3156.9 | |
| Non-Polymers* | Number of molecules | 66 |
| Total formula weight | 13372.6 | |
| All* | Total formula weight | 363536.5 |
