3NC0
Crystal structure of the HIV-1 Rev NES-CRM1-RanGTP nuclear export complex (crystal II)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Exportin-1 | polymer | 1073 | 123367.2 | 2 | UniProt (Q6P5F9) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) | Mus musculus (mouse) | Exp1, Chromosome region maintenance 1 protein homolog |
| 2 | B, E (B, E) | Snurportin-1 | polymer | 362 | 41431.9 | 2 | UniProt (O95149) Pfam (PF11538) Pfam (PF21974) | Homo sapiens (human) | RNA U transporter 1 |
| 3 | C, F (C, F) | GTP-binding nuclear protein Ran | polymer | 176 | 20192.5 | 2 | UniProt (P62826) Pfam (PF00071) | Homo sapiens (human) | GTPase Ran, Ras-related nuclear protein, Ras-like protein TC4, Androgen receptor-associated protein 24 |
| 4 | BA, CA, DA, G, H... (D, E, A, B, C) | GLYCEROL | non-polymer | 92.1 | 10 | Chemie (GOL) PubChem (753) | |||
| 5 | AA, GA, J, K, L... (D, L, A, C) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 12 | Chemie (PEG) PubChem (8117) | |||
| 6 | O (B) | PHENOL | non-polymer | 94.1 | 1 | Chemie (IPH) PubChem (996) | |||
| 7 | EA, Q (F, C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 8 | FA, R (F, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 9 | HA, IA, JA, KA, LA... (A, B, C, D, E...) | water | water | 18.0 | 629 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 1071 (UniProt: Q6P5F9)
B, E: 15 - 360 (UniProt: O95149)
C, F: 5 - 180 (UniProt: P62826)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Val 2 | - | expression tag |
| Pro 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Gln 5 | - | expression tag |
| Leu 6 | - | expression tag |
| Pro 7 | - | expression tag |
| Pro 8 | - | expression tag |
| Leu 9 | - | expression tag |
| Glu 10 | - | expression tag |
| Arg 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Thr 13 | - | expression tag |
| Leu 14 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu 69 | Gln 69 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 369983.2 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 3383.5 | |
| All* | Total formula weight | 373366.7 |
