3NC0
Crystal structure of the HIV-1 Rev NES-CRM1-RanGTP nuclear export complex (crystal II)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Exportin-1 | polymer | 1073 | 123367.2 | 2 | UniProt (Q6P5F9) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) | Mus musculus (mouse) | Exp1, Chromosome region maintenance 1 protein homolog |
| 2 | B, E (B, E) | Snurportin-1 | polymer | 362 | 41431.9 | 2 | UniProt (O95149) Pfam (PF11538) Pfam (PF21974) | Homo sapiens (human) | RNA U transporter 1 |
| 3 | C, F (C, F) | GTP-binding nuclear protein Ran | polymer | 176 | 20192.5 | 2 | UniProt (P62826) Pfam (PF00071) | Homo sapiens (human) | GTPase Ran, Ras-related nuclear protein, Ras-like protein TC4, Androgen receptor-associated protein 24 |
| 4 | BA, CA, DA, G, H... (D, E, A, B, C) | GLYCEROL | non-polymer | 92.1 | 10 | Chemie (GOL) | |||
| 5 | AA, GA, J, K, L... (D, L, A, C) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 12 | Chemie (PEG) | |||
| 6 | O (B) | PHENOL | non-polymer | 94.1 | 1 | Chemie (IPH) | |||
| 7 | EA, Q (F, C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
| 8 | FA, R (F, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 9 | HA, IA, JA, KA, LA... (A, B, C, D, E...) | water | water | 18.0 | 629 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 1071 (UniProt: Q6P5F9)
B, E: 15 - 360 (UniProt: O95149)
C, F: 5 - 180 (UniProt: P62826)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Val 2 | - | expression tag |
| Pro 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Gln 5 | - | expression tag |
| Leu 6 | - | expression tag |
| Pro 7 | - | expression tag |
| Pro 8 | - | expression tag |
| Leu 9 | - | expression tag |
| Glu 10 | - | expression tag |
| Arg 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Thr 13 | - | expression tag |
| Leu 14 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu 69 | Gln 69 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 369983.2 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 3383.5 | |
| All* | Total formula weight | 373366.7 |
