3MP5
Crystal Structure of Human Lyase R41M in complex with HMG-CoA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Hydroxymethylglutaryl-CoA lyase | polymer | 298 | 31551.6 | 6 | UniProt (P35914) Pfam (PF00682) | Homo sapiens (human) | HMG-CoA lyase, HL, 3-hydroxy-3-methylglutarate-CoA lyase |
| 2 | G (B) | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A | non-polymer | 906.6 | 1 | Chemie (HMG) | |||
| 3 | H, I (B, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | J, K, L, M, N... (A, B, C, D, E...) | water | water | 18.0 | 344 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 28 - 325 (UniProt: P35914)
| PDB | External Database | Details |
|---|---|---|
| Met 41 | Arg 41 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 189309.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 955.2 | |
| All* | Total formula weight | 190265.0 |
