Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3MP5

Crystal Structure of Human Lyase R41M in complex with HMG-CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0004419	molecular_function	hydroxymethylglutaryl-CoA lyase activity
A	0005198	molecular_function	structural molecule activity
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005777	cellular_component	peroxisome
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0006552	biological_process	L-leucine catabolic process
A	0006629	biological_process	lipid metabolic process
A	0016829	molecular_function	lyase activity
A	0016833	molecular_function	oxo-acid-lyase activity
A	0030145	molecular_function	manganese ion binding
A	0032991	cellular_component	protein-containing complex
A	0046872	molecular_function	metal ion binding
A	0046951	biological_process	ketone body biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004419	molecular_function	hydroxymethylglutaryl-CoA lyase activity
B	0005198	molecular_function	structural molecule activity
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005777	cellular_component	peroxisome
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0006552	biological_process	L-leucine catabolic process
B	0006629	biological_process	lipid metabolic process
B	0016829	molecular_function	lyase activity
B	0016833	molecular_function	oxo-acid-lyase activity
B	0030145	molecular_function	manganese ion binding
B	0032991	cellular_component	protein-containing complex
B	0046872	molecular_function	metal ion binding
B	0046951	biological_process	ketone body biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0004419	molecular_function	hydroxymethylglutaryl-CoA lyase activity
C	0005198	molecular_function	structural molecule activity
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005777	cellular_component	peroxisome
C	0005782	cellular_component	peroxisomal matrix
C	0005829	cellular_component	cytosol
C	0006552	biological_process	L-leucine catabolic process
C	0006629	biological_process	lipid metabolic process
C	0016829	molecular_function	lyase activity
C	0016833	molecular_function	oxo-acid-lyase activity
C	0030145	molecular_function	manganese ion binding
C	0032991	cellular_component	protein-containing complex
C	0046872	molecular_function	metal ion binding
C	0046951	biological_process	ketone body biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0004419	molecular_function	hydroxymethylglutaryl-CoA lyase activity
D	0005198	molecular_function	structural molecule activity
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005777	cellular_component	peroxisome
D	0005782	cellular_component	peroxisomal matrix
D	0005829	cellular_component	cytosol
D	0006552	biological_process	L-leucine catabolic process
D	0006629	biological_process	lipid metabolic process
D	0016829	molecular_function	lyase activity
D	0016833	molecular_function	oxo-acid-lyase activity
D	0030145	molecular_function	manganese ion binding
D	0032991	cellular_component	protein-containing complex
D	0046872	molecular_function	metal ion binding
D	0046951	biological_process	ketone body biosynthetic process
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0004419	molecular_function	hydroxymethylglutaryl-CoA lyase activity
E	0005198	molecular_function	structural molecule activity
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005777	cellular_component	peroxisome
E	0005782	cellular_component	peroxisomal matrix
E	0005829	cellular_component	cytosol
E	0006552	biological_process	L-leucine catabolic process
E	0006629	biological_process	lipid metabolic process
E	0016829	molecular_function	lyase activity
E	0016833	molecular_function	oxo-acid-lyase activity
E	0030145	molecular_function	manganese ion binding
E	0032991	cellular_component	protein-containing complex
E	0046872	molecular_function	metal ion binding
E	0046951	biological_process	ketone body biosynthetic process
F	0000287	molecular_function	magnesium ion binding
F	0003824	molecular_function	catalytic activity
F	0004419	molecular_function	hydroxymethylglutaryl-CoA lyase activity
F	0005198	molecular_function	structural molecule activity
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005777	cellular_component	peroxisome
F	0005782	cellular_component	peroxisomal matrix
F	0005829	cellular_component	cytosol
F	0006552	biological_process	L-leucine catabolic process
F	0006629	biological_process	lipid metabolic process
F	0016829	molecular_function	lyase activity
F	0016833	molecular_function	oxo-acid-lyase activity
F	0030145	molecular_function	manganese ion binding
F	0032991	cellular_component	protein-containing complex
F	0046872	molecular_function	metal ion binding
F	0046951	biological_process	ketone body biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HMG B 401

Chain	Residue
B	ASP42
B	ASN140
B	ARG149
B	TYR167
B	SER169
B	GLY203
B	THR205
B	HIS235
B	CYS266
B	MG402
B	GLN45
B	SER78
B	LYS80
B	TRP81
B	ASN109
B	PHE127
B	ASN138
B	ILE139

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 402

Chain	Residue
B	ASP42
B	HIS233
B	HIS235
B	ASN275
B	HMG401
B	HOH802

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 403

Chain	Residue
C	ASP42
C	HIS233
C	HIS235
C	HOH692
C	HOH729

Functional Information from PROSITE/UniProt

site_id	PS01062
Number of Residues	10
Details	HMG_COA_LYASE Hydroxymethylglutaryl-coenzyme A lyase active site. SVAGLGGCPY

Chain	Residue	Details
A	SER259-TYR268

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	801
Details	Domain: {"description":"Pyruvate carboxyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01151","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	5
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10115","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	30
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	18
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P38060","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P38060","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)