3L6B
X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine racemase | polymer | 346 | 37455.9 | 1 | UniProt (Q9GZT4) Pfam (PF00291) | Homo sapiens (human) | |
| 2 | B (A) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 1 | Chemie (PLP) | |||
| 3 | C (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 4 | D (A) | MALONATE ION | non-polymer | 102.0 | 1 | Chemie (MLI) | |||
| 5 | E (A) | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence modifications
A: 1 - 340 (UniProt: Q9GZT4)
| PDB | External Database | Details |
|---|---|---|
| Asp 2 | Cys 2 | engineered mutation |
| Asp 6 | Cys 6 | engineered mutation |
| His 341 | - | expression tag |
| His 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
| His 346 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37455.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 404.1 | |
| All* | Total formula weight | 37860.0 |
