3KGC
Isolated ligand binding domain dimer of GluA2 ionotropic glutamate receptor in complex with glutamate, LY 404187 and ZK 200775
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Glutamate receptor 2 | polymer | 263 | 29194.7 | 2 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (rat) | GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, AMPA-selective glutamate receptor 2 |
2 | A | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
4 | A | N-[(2S)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide | non-polymer | 342.5 | 1 | Chemie (LY7) | |||
5 | B | {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | non-polymer | 409.3 | 1 | Chemie (ZK1) | |||
6 | water | water | 18.0 | 518 | Chemie (HOH) |
Sequence modifications
A, B: 4 - 117 (UniProt: P19491)
A, B: 121 - 262 (UniProt: P19491)
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Ala 2 | - | expression tag |
Asn 3 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 118 | - | linker |
Thr 119 | - | linker |
Pro 120 | - | linker |
Ser 242 | Asn 775 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 58389.3 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1091.0 | |
All* | Total formula weight | 59480.3 |