3JSV

Crystal structure of mouse NEMO CoZi in complex with Lys63-linked di-ubiquitin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ubiquitin	polymer	76	8604.8	1	UniProt (P62988) Pfam (PF00240) UniProt (by SIFTS) (P0CG48)	Homo sapiens (human)
2	B (B)	Ubiquitin	polymer	77	8691.9	1	UniProt (P62988) Pfam (PF00240) UniProt (by SIFTS) (P0CG48)	Homo sapiens (human)
3	C, D (C, D)	NF-kappa-B essential modulator	polymer	94	11105.6	2	UniProt (O88522) Pfam (PF16516)	Mus musculus (mouse)	NEMO, NF-kappa-B essential modifier, Inhibitor of nuclear factor kappa-B kinase subunit gamma, IkB kinase subunit gamma, I-kappa-B kinase gamma, IKK-gamma, IKKG, IkB kinase-associated protein 1, IKKAP1, mFIP-3
4	E, F, G, H (A, B, C, D)	water	water		18.0	26	Chemie (HOH)

Sequence modifications

A: 1 - 76 (UniProt: P62988)

PDB	External Database	Details
Arg 63	Lys 63	engineered mutation

B: 1 - 76 (UniProt: P62988)

PDB	External Database	Details
Asp 77	-	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	39508.0
All*	Total formula weight	39508.0

*Water molecules are not included.