3II6
Structure of human Xrcc4 in complex with the tandem BRCT domains of DNA LigaseIV.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | DNA repair protein XRCC4 | polymer | 203 | 23424.5 | 4 | UniProt (Q13426) Pfam (PF06632) Pfam (PF21924) | Homo sapiens (human) | X-ray repair cross-complementing protein 4 |
| 2 | E, F (X, Y) | DNA ligase 4 | polymer | 263 | 30221.4 | 2 | UniProt (P49917) Pfam (PF00533) Pfam (PF11411) | Homo sapiens (human) | DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4 |
| 3 | G, H (Y) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | I, J, K, L, M... (A, B, C, D, X...) | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 203 (UniProt: Q13426)
X, Y: 654 - 911 (UniProt: P49917)
| PDB | External Database | Details |
|---|---|---|
| Glu 60 | Ala 60 | engineered mutation |
| Thr 134 | Ile 134 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 649 | - | expression tag |
| Ala 650 | - | expression tag |
| Met 651 | - | expression tag |
| Gly 652 | - | expression tag |
| Ser 653 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 154140.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 70.9 | |
| All* | Total formula weight | 154211.8 |
