3ID8

Ternary complex of human pancreatic glucokinase crystallized with activator, glucose and AMP-PNP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Glucokinase	polymer	470	52996.2	1	UniProt (P35557) Pfam (PF00349) Pfam (PF03727) In PDB	Homo sapiens (human)	Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D
2	A	alpha-D-glucopyranose	non-polymer		180.2	1	Chemie (GLC)
3	A	2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE	non-polymer		349.4	1	Chemie (MRK)
4	A	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	1	Chemie (ANP)
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	A	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
7		water	water		18.0	125	Chemie (HOH)

Sequence modifications

A: 12 - 465 (UniProt: P35557)

PDB	External Database	Details
Met -4	-	expression tag
Gly -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
Glu 4	-	expression tag
Asn 5	-	expression tag
Leu 6	-	expression tag
Tyr 7	-	expression tag
Phe 8	-	expression tag
Gln 9	-	expression tag
Gly 10	-	expression tag
Met 11	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52996.2
Non-Polymers*	Number of molecules	5
	Total formula weight	1099.2
All*	Total formula weight	54095.3

*Water molecules are not included.