3HS0

Cobra Venom Factor (CVF) in complex with human factor B

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, F)	Cobra venom factor	polymer	627	69582.0	2	UniProt (Q91132)	Naja kaouthia	CVF, Complement C3 homolog, Cobra venom factor alpha chain, Cobra venom factor gamma chain, Cobra venom factor beta chain
2	B, F (B, G)	Cobra venom factor	polymer	252	28418.6	2	UniProt (Q91132)	Naja kaouthia	CVF, Complement C3 homolog, Cobra venom factor alpha chain, Cobra venom factor gamma chain, Cobra venom factor beta chain
3	C, G (C, H)	Cobra venom factor	polymer	379	43626.5	2	UniProt (Q91132)	Naja kaouthia	CVF, Complement C3 homolog, Cobra venom factor alpha chain, Cobra venom factor gamma chain, Cobra venom factor beta chain
4	D, H (D, I)	Complement factor B	polymer	741	83194.9	2	UniProt (P00751) Pfam (PF00084) Pfam (PF00092) Pfam (PF00089)	Homo sapiens (human)	C3/C5 convertase, Properdin factor B, Glycine-rich beta glycoprotein, GBG, PBF2, Complement factor B Ba fragment, Complement factor B Bb fragment
5	I, J (E, J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
6	K, M, N, O, Q... (A, C, D, F, H...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)
7	L, P, R, U (A, D, F, I)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
8	AA, V, W, X, Y... (I, A, C, D, F...)	water	water		18.0	8	Chemie (HOH)

Sequence modifications

D, I: 1 - 739 (UniProt: P00751)

PDB	External Database	Details
Gly 254	Asp 279	engineered mutation
Asp 260	Asn 285	engineered mutation
Ala 740	-	insertion
Ala 741	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	449643.9
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	11
	Total formula weight	1645.7
All*	Total formula weight	452138.4

*Water molecules are not included.