3HS0
Cobra Venom Factor (CVF) in complex with human factor B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, F) | Cobra venom factor | polymer | 627 | 69582.0 | 2 | UniProt (Q91132) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) Pfam (PF07703) | Naja kaouthia | CVF, Complement C3 homolog, Cobra venom factor alpha chain, Cobra venom factor gamma chain, Cobra venom factor beta chain |
| 2 | B, F (B, G) | Cobra venom factor | polymer | 252 | 28418.6 | 2 | UniProt (Q91132) Pfam (PF00207) Pfam (PF21406) | Naja kaouthia | CVF, Complement C3 homolog, Cobra venom factor alpha chain, Cobra venom factor gamma chain, Cobra venom factor beta chain |
| 3 | C, G (C, H) | Cobra venom factor | polymer | 379 | 43626.5 | 2 | UniProt (Q91132) Pfam (PF01759) Pfam (PF21308) Pfam (PF07677) | Naja kaouthia | CVF, Complement C3 homolog, Cobra venom factor alpha chain, Cobra venom factor gamma chain, Cobra venom factor beta chain |
| 4 | D, H (D, I) | Complement factor B | polymer | 741 | 83194.9 | 2 | UniProt (P00751) Pfam (PF00084) Pfam (PF00092) Pfam (PF00089) | Homo sapiens (human) | C3/C5 convertase, Properdin factor B, Glycine-rich beta glycoprotein, GBG, PBF2, Complement factor B Ba fragment, Complement factor B Bb fragment |
| 5 | I, J (E, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | K, M, N, O, Q... (A, C, D, F, H...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 7 | L, P, R, U (A, D, F, I) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 8 | AA, V, W, X, Y... (I, A, C, D, F...) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
D, I: 1 - 739 (UniProt: P00751)
| PDB | External Database | Details |
|---|---|---|
| Gly 254 | Asp 279 | engineered mutation |
| Asp 260 | Asn 285 | engineered mutation |
| Ala 740 | - | insertion |
| Ala 741 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 449643.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1645.7 | |
| All* | Total formula weight | 452138.4 |
