3HS0
Cobra Venom Factor (CVF) in complex with human factor B
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004866 | molecular_function | endopeptidase inhibitor activity |
| B | 0004866 | molecular_function | endopeptidase inhibitor activity |
| C | 0005576 | cellular_component | extracellular region |
| D | 0001848 | molecular_function | complement binding |
| D | 0002376 | biological_process | immune system process |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006508 | biological_process | proteolysis |
| D | 0006956 | biological_process | complement activation |
| D | 0006957 | biological_process | complement activation, alternative pathway |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0009617 | biological_process | response to bacterium |
| D | 0009986 | cellular_component | cell surface |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0045087 | biological_process | innate immune response |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0072562 | cellular_component | blood microparticle |
| D | 0106139 | cellular_component | symbiont cell surface |
| F | 0004866 | molecular_function | endopeptidase inhibitor activity |
| G | 0004866 | molecular_function | endopeptidase inhibitor activity |
| H | 0005576 | cellular_component | extracellular region |
| I | 0001848 | molecular_function | complement binding |
| I | 0002376 | biological_process | immune system process |
| I | 0004252 | molecular_function | serine-type endopeptidase activity |
| I | 0005515 | molecular_function | protein binding |
| I | 0005576 | cellular_component | extracellular region |
| I | 0005615 | cellular_component | extracellular space |
| I | 0005886 | cellular_component | plasma membrane |
| I | 0006508 | biological_process | proteolysis |
| I | 0006956 | biological_process | complement activation |
| I | 0006957 | biological_process | complement activation, alternative pathway |
| I | 0008233 | molecular_function | peptidase activity |
| I | 0008236 | molecular_function | serine-type peptidase activity |
| I | 0009617 | biological_process | response to bacterium |
| I | 0009986 | cellular_component | cell surface |
| I | 0016787 | molecular_function | hydrolase activity |
| I | 0045087 | biological_process | innate immune response |
| I | 0070062 | cellular_component | extracellular exosome |
| I | 0072562 | cellular_component | blood microparticle |
| I | 0106139 | cellular_component | symbiont cell surface |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DDNEDGFIAdsDI |
| Chain | Residue | Details |
| B | ASP711-ILE723 |
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| D | LEU497-CYS502 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. NTcrGDSGGPLI |
| Chain | Residue | Details |
| D | ASN668-ILE679 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| D | HIS501 | |
| D | ASP551 | |
| D | SER674 | |
| I | HIS501 | |
| I | ASP551 | |
| I | SER674 | |
| F | VAL518 | |
| F | ASP520 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6546754 |
| Chain | Residue | Details |
| D | ASN97 | |
| D | ASP260 | |
| I | ASN97 | |
| I | ASP260 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754 |
| Chain | Residue | Details |
| D | ASN117 | |
| I | ASN117 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:2006911 |
| Chain | Residue | Details |
| D | LYS266 | |
| I | LYS266 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754 |
| Chain | Residue | Details |
| D | ASN353 | |
| I | ASN353 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | SER674 | |
| D | ASP551 | |
| D | HIS501 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| I | SER674 | |
| I | GLY672 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | GLY675 | |
| D | SER674 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| I | GLY675 | |
| I | SER674 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| I | SER674 | |
| I | ASP551 | |
| I | HIS501 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | GLY675 | |
| D | SER674 | |
| D | ASP551 | |
| D | HIS501 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| I | GLY675 | |
| I | SER674 | |
| I | ASP551 | |
| I | HIS501 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | SER674 | |
| D | ASP551 | |
| D | GLY672 | |
| D | HIS501 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| I | SER674 | |
| I | ASP551 | |
| I | GLY672 | |
| I | HIS501 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | ASP551 | |
| D | HIS501 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| I | ASP551 | |
| I | HIS501 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | SER674 | |
| D | GLY672 |
