3HMO
Crystal structure of human Mps1 catalytic domain in complex with the inhibitor staurosporine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity protein kinase TTK | polymer | 342 | 39086.4 | 1 | UniProt (P33981) Pfam (PF00069) | Homo sapiens (human) | Phosphotyrosine picked threonine-protein kinase, PYT |
| 2 | B (A) | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL | non-polymer | 310.4 | 1 | Chemie (7PE) PubChem (526557) | |||
| 3 | C (A) | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) PubChem (71203703) PubChem (42610657) PubChem (44299148) PubChem (49831000) PubChem (25322871) PubChem (28684983) PubChem (44120114) PubChem (44537813) PubChem (46864193) PubChem (358479) PubChem (5280487) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (68262703) PubChem (68306294) PubChem (73953205) PubChem (12046017) PubChem (86306248) PubChem (5279) PubChem (44259) PubChem (451705) PubChem (122130844) PubChem (5459111) PubChem (6419748) PubChem (9804568) PubChem (9937179) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898) | |||
| 4 | D, E, F (A) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 3 | Chemie (IPA) | |||
| 5 | G, H, I, J (A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) PubChem (753) | |||
| 6 | K (A) | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence modifications
A: 510 - 809 (UniProt: P33981)
| PDB | External Database | Details |
|---|---|---|
| His 468 | - | expression tag |
| His 469 | - | expression tag |
| His 470 | - | expression tag |
| His 471 | - | expression tag |
| His 472 | - | expression tag |
| His 473 | - | expression tag |
| Ser 474 | - | expression tag |
| Ser 475 | - | expression tag |
| Gly 476 | - | expression tag |
| Leu 477 | - | expression tag |
| Val 478 | - | expression tag |
| Pro 479 | - | expression tag |
| Arg 480 | - | expression tag |
| Gly 481 | - | expression tag |
| Ser 482 | - | expression tag |
| Gly 483 | - | expression tag |
| Met 484 | - | expression tag |
| Lys 485 | - | expression tag |
| Glu 486 | - | expression tag |
| Thr 487 | - | expression tag |
| Ala 488 | - | expression tag |
| Ala 489 | - | expression tag |
| Ala 490 | - | expression tag |
| Lys 491 | - | expression tag |
| Phe 492 | - | expression tag |
| Glu 493 | - | expression tag |
| Arg 494 | - | expression tag |
| Gln 495 | - | expression tag |
| His 496 | - | expression tag |
| Met 497 | - | expression tag |
| Asp 498 | - | expression tag |
| Ser 499 | - | expression tag |
| Pro 500 | - | expression tag |
| Asp 501 | - | expression tag |
| Leu 502 | - | expression tag |
| Gly 503 | - | expression tag |
| Thr 504 | - | expression tag |
| Asp 505 | - | expression tag |
| Asp 506 | - | expression tag |
| Asp 507 | - | expression tag |
| Asp 508 | - | expression tag |
| Lys 509 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39086.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1325.6 | |
| All* | Total formula weight | 40412.0 |
