3G7V
Islet Amyloid Polypeptide (IAPP or Amylin) fused to Maltose Binding Protein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Maltose-binding periplasmic protein, Islet amyloid polypeptide fusion protein | polymer | 408 | 44442.2 | 4 | UniProt (P0AEX9) UniProt (P10997) Pfam (PF01547) Pfam (PF00214) | Escherichia coli | MMBP, Maltodextrin-binding protein, Amylin, Diabetes-associated peptide, DAP, Insulinoma amyloid peptide |
| 2 | E, F, G, H (E, F, G, H) | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 4 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
| 3 | AA, I, J, L, M... (D, A, B, C) | SULFATE ION | non-polymer | 96.1 | 15 | Chemie (SO4) | |||
| 4 | BA, K, Q, R, X (D, A, B, C) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | CA, DA, EA, FA (A, B, C, D) | water | water | 18.0 | 862 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 366 (UniProt: P0AEX9)
A, B, C, D: 371 - 406 (UniProt: P10997)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ala 359 | Glu 385 | engineered mutation |
| Ala 362 | Lys 388 | engineered mutation |
| Ala 363 | Asp 389 | engineered mutation |
| Asn 367 | - | linker |
| Ala 368 | - | linker |
| Ala 369 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 370 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 177768.7 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1369.2 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 1901.4 | |
| All* | Total formula weight | 181039.3 |
