3G7V

Islet Amyloid Polypeptide (IAPP or Amylin) fused to Maltose Binding Protein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Maltose-binding periplasmic protein, Islet amyloid polypeptide fusion protein	polymer	408	44442.2	4	UniProt (P0AEX9) UniProt (P10997) Pfam (PF01547) Pfam (PF00214) In PDB	Escherichia coli	MMBP, Maltodextrin-binding protein, Amylin, Diabetes-associated peptide, DAP, Insulinoma amyloid peptide
2	E, F, G, H	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	4	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)		alpha-maltose
3	D, A, B, C	SULFATE ION	non-polymer		96.1	15	Chemie (SO4)
4	D, A, B, C	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
5		water	water		18.0	862	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 366 (UniProt: P0AEX9)

PDB	External Database	Details
Met 0	-	initiating methionine
Ala 359	Glu 385	engineered mutation
Ala 362	Lys 388	engineered mutation
Ala 363	Asp 389	engineered mutation
Asn 367	-	linker
Ala 368	-	linker
Ala 369	-	linker

A, B, C, D: 371 - 406 (UniProt: P10997)

PDB	External Database	Details
Ala 370	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	177768.7
Branched	Number of molecules	4
	Total formula weight	1369.2
Non-Polymers*	Number of molecules	20
	Total formula weight	1901.4
All*	Total formula weight	181039.3

*Water molecules are not included.