3G1N

Catalytic domain of the human E3 ubiquitin-protein ligase HUWE1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	E3 ubiquitin-protein ligase HUWE1	polymer	388	45528.5	2	UniProt (Q7Z6Z7) Pfam (PF00632) In PDB	Homo sapiens (human)	HECT, UBA and WWE domain-containing protein 1, Upstream regulatory element-binding protein 1, URE-binding protein 1, URE-B1, Mcl-1 ubiquitin ligase E3, Mule, ARF-binding protein 1, ARF-BP1, Large structure of UREB1, LASU1, Homologous to E6AP carboxyl terminus homologous protein 9, HectH9
2	A, B	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
3		water	water		18.0	140	Chemie (HOH)

Sequence modifications

A, B: 4005 - 4374 (UniProt: Q7Z6Z7)

PDB	External Database	Details
Met 3987	-	expression tag
His 3988	-	expression tag
His 3989	-	expression tag
His 3990	-	expression tag
His 3991	-	expression tag
His 3992	-	expression tag
His 3993	-	expression tag
Ser 3994	-	expression tag
Ser 3995	-	expression tag
Gly 3996	-	expression tag
Arg 3997	-	expression tag
Glu 3998	-	expression tag
Asn 3999	-	expression tag
Leu 4000	-	expression tag
Tyr 4001	-	expression tag
Phe 4002	-	expression tag
Gln 4003	-	expression tag
Gly 4004	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	91057.0
Non-Polymers*	Number of molecules	2
	Total formula weight	46.0
All*	Total formula weight	91103.0

*Water molecules are not included.