3FCS
Structure of complete ectodomain of integrin aIIBb3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Integrin, alpha 2b | polymer | 959 | 104460.7 | 2 | UniProt (Q17R67) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806) UniProt (by SIFTS) (P08514) | Homo sapiens (human) | |
| 2 | B, D (B, D) | Integrin beta-3 | polymer | 690 | 76316.9 | 2 | UniProt (P05106) Pfam (PF07965) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) Pfam (PF07974) | Homo sapiens (human) | Platelet membrane glycoprotein IIIa, GPIIIa |
| 3 | E, H, J, K, L... (E, H, J, K, L...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 7 | In PDB GlyTouCan (G42666HT) | |||
| 4 | F (F) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G48068RF) | |||
| 5 | G (G) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 6 | I (I) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G75436UI) | |||
| 7 | AA, BA, CA, DA, MA... (C, D, A, B) | CALCIUM ION | non-polymer | 40.1 | 14 | Chemie (CA) | |||
| 8 | EA, FA, OA, T, U (C, D, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 9 | GA, HA, IA, JA, KA... (C, A) | IMIDAZOLE | non-polymer | 69.1 | 6 | Chemie (IMD) | |||
| 10 | LA, W (D, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 11 | PA, QA, RA, SA (A, B, C, D) | water | water | 18.0 | 678 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 958 (UniProt: Q17R67)
B, D: 1 - 690 (UniProt: P05106)
| PDB | External Database | Details |
|---|---|---|
| Cys 959 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Cys 688 | Pro 714 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 361555.3 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 5216.9 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 2130.3 | |
| All* | Total formula weight | 368902.4 |
