3EZQ

Crystal Structure of the Fas/FADD Death Domain Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I...	Tumor necrosis factor receptor superfamily member 6	polymer	115	13061.8	8	UniProt (P25445) Pfam (PF00531) In PDB	Homo sapiens (Human)	FASLG receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, CD95 antigen
2	B, D, F, H, J...	Protein FADD	polymer	122	13955.5	8	UniProt (Q13158) Pfam (PF00531) In PDB	Homo sapiens (Human)	FAS-associated death domain protein, FAS-associating death domain-containing protein, Mediator of receptor induced toxicity
3	J, K, M, O, A...	SULFATE ION	non-polymer		96.1	12	Chemie (SO4)
4	J, K, M, P, A...	SODIUM ION	non-polymer		23.0	8	Chemie (NA)
5		water	water		18.0	177	Chemie (HOH)

Sequence modifications

A, C, E, G, I, K, M, O: 223 - 335 (UniProt: P25445)

PDB	External Database	Details
Leu 336	-	expression tag
Glu 337	-	expression tag

B, D, F, H, J, L, N, P: 93 - 208 (UniProt: Q13158)

PDB	External Database	Details
His 209	-	expression tag
His 210	-	expression tag
His 211	-	expression tag
His 212	-	expression tag
His 213	-	expression tag
His 214	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	216138.8
Non-Polymers*	Number of molecules	20
	Total formula weight	1336.7
All*	Total formula weight	217475.5

*Water molecules are not included.