3EDQ

Crystal structure of Caspase-3 with inhibitor AC-LDESD-CHO

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Caspase-3	polymer	147	16639.9	2	UniProt (P42574) Pfam (PF00656) In PDB	Homo sapiens (Human)	CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Yama protein, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12
2	B, D	Caspase-3	polymer	108	12739.5	2	UniProt (P42574) Pfam (PF00656) In PDB	Homo sapiens (Human)	CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Yama protein, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12
3	E, F	AC-LDESD-CHO peptide	polymer	6	587.6	2			CASP-3; APOPAIN; CYSTEINE PROTEASE CPP32; YAMA PROTEIN; CPP-32; SREBP CLEAVAGE ACTIVITY 1; SCA-1
4		water	water		18.0	276	Chemie (HOH)

Sequence modifications

B, D: 176 - 277 (UniProt: P42574)

PDB	External Database	Details
His 278	-	expression tag
His 279	-	expression tag
His 280	-	expression tag
His 281	-	expression tag
His 282	-	expression tag
His 283	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	59933.9
All*	Total formula weight	59933.9

*Water molecules are not included.