3ECS

Crystal structure of human eIF2B alpha

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Translation initiation factor eIF-2B subunit alpha	polymer	315	35253.6	8	UniProt (Q14232) Pfam (PF01008) In PDB	Homo sapiens (human)	eukaryotic translation initiation factor 2B alpha, eIF-2B GDP-GTP exchange factor subunit alpha
2	A, B, C, D, E...	SULFATE ION	non-polymer		96.1	10	Chemie (SO4)
3	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
4		water	water		18.0	185	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 305 (UniProt: Q14232)

PDB	External Database	Details
Ala 306	-	EXPRESSION TAG
Ala 307	-	EXPRESSION TAG
Ala 308	-	EXPRESSION TAG
Glu 309	-	EXPRESSION TAG
His 310	-	EXPRESSION TAG
His 311	-	EXPRESSION TAG
His 312	-	EXPRESSION TAG
His 313	-	EXPRESSION TAG
His 314	-	EXPRESSION TAG
His 315	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	282029.1
Non-Polymers*	Number of molecules	11
	Total formula weight	996.1
All*	Total formula weight	283025.1

*Water molecules are not included.