Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3ECS

Crystal structure of human eIF2B alpha

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002183	biological_process	cytoplasmic translational initiation
A	0003743	molecular_function	translation initiation factor activity
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
A	0005886	cellular_component	plasma membrane
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0009408	biological_process	response to heat
A	0009749	biological_process	response to glucose
A	0014003	biological_process	oligodendrocyte development
A	0016020	cellular_component	membrane
A	0042802	molecular_function	identical protein binding
A	0043434	biological_process	response to peptide hormone
A	0045948	biological_process	positive regulation of translational initiation
A	0050852	biological_process	T cell receptor signaling pathway
B	0002183	biological_process	cytoplasmic translational initiation
B	0003743	molecular_function	translation initiation factor activity
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
B	0005886	cellular_component	plasma membrane
B	0006412	biological_process	translation
B	0006413	biological_process	translational initiation
B	0009408	biological_process	response to heat
B	0009749	biological_process	response to glucose
B	0014003	biological_process	oligodendrocyte development
B	0016020	cellular_component	membrane
B	0042802	molecular_function	identical protein binding
B	0043434	biological_process	response to peptide hormone
B	0045948	biological_process	positive regulation of translational initiation
B	0050852	biological_process	T cell receptor signaling pathway
C	0002183	biological_process	cytoplasmic translational initiation
C	0003743	molecular_function	translation initiation factor activity
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
C	0005886	cellular_component	plasma membrane
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation
C	0009408	biological_process	response to heat
C	0009749	biological_process	response to glucose
C	0014003	biological_process	oligodendrocyte development
C	0016020	cellular_component	membrane
C	0042802	molecular_function	identical protein binding
C	0043434	biological_process	response to peptide hormone
C	0045948	biological_process	positive regulation of translational initiation
C	0050852	biological_process	T cell receptor signaling pathway
D	0002183	biological_process	cytoplasmic translational initiation
D	0003743	molecular_function	translation initiation factor activity
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
D	0005886	cellular_component	plasma membrane
D	0006412	biological_process	translation
D	0006413	biological_process	translational initiation
D	0009408	biological_process	response to heat
D	0009749	biological_process	response to glucose
D	0014003	biological_process	oligodendrocyte development
D	0016020	cellular_component	membrane
D	0042802	molecular_function	identical protein binding
D	0043434	biological_process	response to peptide hormone
D	0045948	biological_process	positive regulation of translational initiation
D	0050852	biological_process	T cell receptor signaling pathway
E	0002183	biological_process	cytoplasmic translational initiation
E	0003743	molecular_function	translation initiation factor activity
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
E	0005886	cellular_component	plasma membrane
E	0006412	biological_process	translation
E	0006413	biological_process	translational initiation
E	0009408	biological_process	response to heat
E	0009749	biological_process	response to glucose
E	0014003	biological_process	oligodendrocyte development
E	0016020	cellular_component	membrane
E	0042802	molecular_function	identical protein binding
E	0043434	biological_process	response to peptide hormone
E	0045948	biological_process	positive regulation of translational initiation
E	0050852	biological_process	T cell receptor signaling pathway
F	0002183	biological_process	cytoplasmic translational initiation
F	0003743	molecular_function	translation initiation factor activity
F	0005085	molecular_function	guanyl-nucleotide exchange factor activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
F	0005886	cellular_component	plasma membrane
F	0006412	biological_process	translation
F	0006413	biological_process	translational initiation
F	0009408	biological_process	response to heat
F	0009749	biological_process	response to glucose
F	0014003	biological_process	oligodendrocyte development
F	0016020	cellular_component	membrane
F	0042802	molecular_function	identical protein binding
F	0043434	biological_process	response to peptide hormone
F	0045948	biological_process	positive regulation of translational initiation
F	0050852	biological_process	T cell receptor signaling pathway
G	0002183	biological_process	cytoplasmic translational initiation
G	0003743	molecular_function	translation initiation factor activity
G	0005085	molecular_function	guanyl-nucleotide exchange factor activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
G	0005886	cellular_component	plasma membrane
G	0006412	biological_process	translation
G	0006413	biological_process	translational initiation
G	0009408	biological_process	response to heat
G	0009749	biological_process	response to glucose
G	0014003	biological_process	oligodendrocyte development
G	0016020	cellular_component	membrane
G	0042802	molecular_function	identical protein binding
G	0043434	biological_process	response to peptide hormone
G	0045948	biological_process	positive regulation of translational initiation
G	0050852	biological_process	T cell receptor signaling pathway
H	0002183	biological_process	cytoplasmic translational initiation
H	0003743	molecular_function	translation initiation factor activity
H	0005085	molecular_function	guanyl-nucleotide exchange factor activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
H	0005886	cellular_component	plasma membrane
H	0006412	biological_process	translation
H	0006413	biological_process	translational initiation
H	0009408	biological_process	response to heat
H	0009749	biological_process	response to glucose
H	0014003	biological_process	oligodendrocyte development
H	0016020	cellular_component	membrane
H	0042802	molecular_function	identical protein binding
H	0043434	biological_process	response to peptide hormone
H	0045948	biological_process	positive regulation of translational initiation
H	0050852	biological_process	T cell receptor signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	SER131
A	ARG132
A	VAL133
A	LYS234
A	HOH1052
A	HOH1093

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 509

Chain	Residue
F	LYS110
A	LYS120
A	ASP121
A	LYS146

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 601

Chain	Residue
A	ARG108
A	ARG136

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 502

Chain	Residue
B	SER131
B	ARG132
B	VAL133
B	ALA197
B	LYS234

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 503

Chain	Residue
C	SER131
C	ARG132
C	VAL133
C	LYS234

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 504

Chain	Residue
D	SER131
D	ARG132
D	VAL133
D	LYS234

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 505

Chain	Residue
E	SER131
E	ARG132
E	VAL133
E	GLU231
E	LYS234

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 F 506

Chain	Residue
F	SER131
F	ARG132
F	VAL133
F	ALA197
F	LYS234
F	HOH1049

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 510

Chain	Residue
A	LYS110
F	LYS120
F	ASP121
F	LYS146

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 G 507

Chain	Residue
G	ARG108
G	SER131
G	ARG132
G	VAL133
G	LYS234
G	HOH1083

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 508

Chain	Residue
H	SER131
H	ARG132
H	VAL133
H	LYS234

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)