3DPL
Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | C | Cullin-5 | polymer | 382 | 44992.2 | 1 | UniProt (Q93034) Pfam (PF00888) Pfam (PF10557) In PDB | Homo sapiens | CUL-5, Vasopressin-activated calcium-mobilizing receptor, VACM-1 |
| 2 | R | RING-box protein 1 | polymer | 106 | 12089.7 | 1 | UniProt (P62877) Pfam (PF12678) In PDB | Homo sapiens | Rbx1, Regulator of cullin-1, RING finger protein 75, Protein ZYP |
| 3 | R | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
C: 401 - 780 (UniProt: Q93034)
R: 5 - 108 (UniProt: P62877)
| PDB | External Database | Details |
|---|---|---|
| Gly 399 | - | expression tag |
| Ser 400 | - | expression tag |
| Glu 407 | Leu 407 | engineered mutation |
| Lys 439 | Leu 439 | engineered mutation |
| Lys 440 | Val 440 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Ser 4 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57081.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 196.2 | |
| All* | Total formula weight | 57278.1 |
