3DOX
X-ray structure of HIV-1 protease in situ product complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HIV-1 PROTEASE | polymer | 203 | 21902.8 | 1 | UniProt (P04585) Pfam (PF00077) | Human immunodeficiency virus type 1 (isolate HXB2 group M subtype B) (HIV-1 HIV-1 M:B_HXB2R) | Pr160Gag-Pol, Matrix protein p17, MA, Capsid protein p24, CA, Spacer peptide p2, Nucleocapsid protein p7, NC, Transframe peptide, TF, p6-pol, p6*, Protease, Retropepsin, PR, Reverse transcriptase/ribonuclease H, p66 RT, p51 RT, p15, Integrase, IN |
| 2 | B (P) | A PEPTIDE SUBSTRATE-SQNY | polymer | 4 | 510.5 | 1 | |||
| 3 | C (Q) | A PEPTIDE SUBSTRATE-PIV | polymer | 3 | 327.4 | 1 | |||
| 4 | D, E, F (A, P, Q) | water | water | 18.0 | 193 | Chemie (HOH) |
Sequence modifications
A: 1 - 99 (UniProt: P04585)
A: 1001 - 1099 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Met 95 | Cys 583 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 996 | - | SEE REMARK 999 |
| Gly 997 | - | SEE REMARK 999 |
| Ser 998 | - | SEE REMARK 999 |
| Ser 999 | - | SEE REMARK 999 |
| Gly 1000 | - | SEE REMARK 999 |
| Ala 1095 | Cys 583 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 22740.7 | |
| All* | Total formula weight | 22740.7 |
