3CSY
Crystal structure of the trimeric prefusion Ebola virus glycoprotein in complex with a neutralizing antibody from a human survivor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Fab KZ52 heavy chain | polymer | 226 | 24208.6 | 4 | Homo sapiens (human) | ||
| 2 | B, D, F, H (B, D, F, H) | Fab KZ52 light chain | polymer | 217 | 23943.5 | 4 | Homo sapiens (human) | ||
| 3 | I, K, M, O (I, K, M, O) | Envelope glycoprotein GP1 | polymer | 334 | 37027.5 | 4 | UniProt (Q05320) Pfam (PF01611) | Ebola virus - Mayinga Zaire 1976 | |
| 4 | J, L, N, P (J, L, N, P) | Envelope glycoprotein GP2 | polymer | 131 | 14779.7 | 4 | UniProt (P87666) Pfam (PF22307) UniProt (by SIFTS) (Q05320) | Ebola virus - Mayinga Zaire 1976 | |
| 5 | Q, U, W (Q, U, W) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 6 | R, V (R, V) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 7 | S (S) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 8 | T, X (T, X) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1114.0 | 2 | In PDB GlyTouCan (G61751GZ) |
Sequence modifications
I, K, M, O: 32 - 311 (UniProt: Q05320)
| PDB | External Database | Details |
|---|---|---|
| Tyr 16 | - | expression tag |
| Pro 17 | - | expression tag |
| Tyr 18 | - | expression tag |
| Asp 19 | - | expression tag |
| Val 20 | - | expression tag |
| Pro 21 | - | expression tag |
| Asp 22 | - | expression tag |
| Tyr 23 | - | expression tag |
| Ala 24 | - | expression tag |
| Ile 25 | - | expression tag |
| Glu 26 | - | expression tag |
| Gly 27 | - | expression tag |
| Arg 28 | - | expression tag |
| Gly 29 | - | expression tag |
| Ala 30 | - | expression tag |
| Arg 31 | - | expression tag |
| Val 42 | Thr 42 | engineered mutation |
| Val 230 | Thr 230 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 399836.8 | |
| Branched | Number of molecules | 8 |
| Total formula weight | 6233.7 | |
| All* | Total formula weight | 406070.5 |
