3CSY
Crystal structure of the trimeric prefusion Ebola virus glycoprotein in complex with a neutralizing antibody from a human survivor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E, G | Fab KZ52 heavy chain | polymer | 226 | 24208.6 | 4 | Homo sapiens (human) | ||
2 | B, D, F, H | Fab KZ52 light chain | polymer | 217 | 23943.5 | 4 | Homo sapiens (human) | ||
3 | I, K, M, O | Envelope glycoprotein GP1 | polymer | 334 | 37027.5 | 4 | UniProt (Q05320) Pfam (PF01611) In PDB | Ebola virus - Mayinga Zaire 1976 | |
4 | J, L, N, P | Envelope glycoprotein GP2 | polymer | 131 | 14779.7 | 4 | UniProt (P87666) Pfam (PF22307) UniProt (by SIFTS) (Q05320) In PDB | Ebola virus - Mayinga Zaire 1976 | |
5 | Q, U, W | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
6 | R, V | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
7 | S | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
8 | T, X | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1114.0 | 2 | In PDB GlyTouCan (G61751GZ) |
Sequence modifications
I, K, M, O: 32 - 311 (UniProt: Q05320)
PDB | External Database | Details |
---|---|---|
Tyr 16 | - | expression tag |
Pro 17 | - | expression tag |
Tyr 18 | - | expression tag |
Asp 19 | - | expression tag |
Val 20 | - | expression tag |
Pro 21 | - | expression tag |
Asp 22 | - | expression tag |
Tyr 23 | - | expression tag |
Ala 24 | - | expression tag |
Ile 25 | - | expression tag |
Glu 26 | - | expression tag |
Gly 27 | - | expression tag |
Arg 28 | - | expression tag |
Gly 29 | - | expression tag |
Ala 30 | - | expression tag |
Arg 31 | - | expression tag |
Val 42 | Thr 42 | engineered mutation |
Val 230 | Thr 230 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 16 |
Total formula weight | 399836.8 | |
Branched | Number of molecules | 8 |
Total formula weight | 6233.7 | |
All* | Total formula weight | 406070.5 |