3CSY

Crystal structure of the trimeric prefusion Ebola virus glycoprotein in complex with a neutralizing antibody from a human survivor

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0002250	biological_process	adaptive immune response
B	0003823	molecular_function	antigen binding
B	0005576	cellular_component	extracellular region
B	0005886	cellular_component	plasma membrane
B	0006955	biological_process	immune response
B	0016064	biological_process	immunoglobulin mediated immune response
B	0050853	biological_process	B cell receptor signaling pathway
B	0070062	cellular_component	extracellular exosome
B	0071735	cellular_component	IgG immunoglobulin complex
B	0071738	cellular_component	IgD immunoglobulin complex
B	0071742	cellular_component	IgE immunoglobulin complex
B	0071745	cellular_component	IgA immunoglobulin complex
B	0071753	cellular_component	IgM immunoglobulin complex
B	0072562	cellular_component	blood microparticle
D	0002250	biological_process	adaptive immune response
D	0003823	molecular_function	antigen binding
D	0005576	cellular_component	extracellular region
D	0005886	cellular_component	plasma membrane
D	0006955	biological_process	immune response
D	0016064	biological_process	immunoglobulin mediated immune response
D	0050853	biological_process	B cell receptor signaling pathway
D	0070062	cellular_component	extracellular exosome
D	0071735	cellular_component	IgG immunoglobulin complex
D	0071738	cellular_component	IgD immunoglobulin complex
D	0071742	cellular_component	IgE immunoglobulin complex
D	0071745	cellular_component	IgA immunoglobulin complex
D	0071753	cellular_component	IgM immunoglobulin complex
D	0072562	cellular_component	blood microparticle
F	0002250	biological_process	adaptive immune response
F	0003823	molecular_function	antigen binding
F	0005576	cellular_component	extracellular region
F	0005886	cellular_component	plasma membrane
F	0006955	biological_process	immune response
F	0016064	biological_process	immunoglobulin mediated immune response
F	0050853	biological_process	B cell receptor signaling pathway
F	0070062	cellular_component	extracellular exosome
F	0071735	cellular_component	IgG immunoglobulin complex
F	0071738	cellular_component	IgD immunoglobulin complex
F	0071742	cellular_component	IgE immunoglobulin complex
F	0071745	cellular_component	IgA immunoglobulin complex
F	0071753	cellular_component	IgM immunoglobulin complex
F	0072562	cellular_component	blood microparticle
H	0002250	biological_process	adaptive immune response
H	0003823	molecular_function	antigen binding
H	0005576	cellular_component	extracellular region
H	0005886	cellular_component	plasma membrane
H	0006955	biological_process	immune response
H	0016064	biological_process	immunoglobulin mediated immune response
H	0050853	biological_process	B cell receptor signaling pathway
H	0070062	cellular_component	extracellular exosome
H	0071735	cellular_component	IgG immunoglobulin complex
H	0071738	cellular_component	IgD immunoglobulin complex
H	0071742	cellular_component	IgE immunoglobulin complex
H	0071745	cellular_component	IgA immunoglobulin complex
H	0071753	cellular_component	IgM immunoglobulin complex
H	0072562	cellular_component	blood microparticle

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
A	TYR206-HIS212
B	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	24
Details	Site: {"description":"Involved in receptor recognition and/or post-binding events","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	23
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	30
Details	Region: {"description":"Fusion peptide","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	164
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---