3CPW
The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | 23S RIBOSOMAL RNA | polymer | 2922 | 946017.4 | 1 | GenBank (3377779) | HALOARCULA MARISMORTUI | |
| 2 | B (9) | 5S RIBOSOMAL RNA | polymer | 122 | 39318.4 | 1 | GenBank (3377779) | HALOARCULA MARISMORTUI | |
| 3 | C (A) | 50S ribosomal protein L2P | polymer | 240 | 25354.7 | 1 | UniProt (P20276) Pfam (PF00181) Pfam (PF03947) | Haloarcula marismortui (Halobacterium marismortui) | |
| 4 | D (B) | 50S ribosomal protein L3P | polymer | 338 | 37396.4 | 1 | UniProt (P20279) Pfam (PF00297) | Haloarcula marismortui (Halobacterium marismortui) | Hmal2, Hl4 |
| 5 | E (C) | 50S ribosomal protein L4P | polymer | 246 | 26457.1 | 1 | UniProt (P12735) Pfam (PF00573) | Haloarcula marismortui (Halobacterium marismortui) | Hmal3, Hl1 |
| 6 | F (D) | 50S ribosomal protein L5P | polymer | 177 | 19551.7 | 1 | UniProt (P14124) Pfam (PF00281) Pfam (PF00673) | Haloarcula marismortui (Halobacterium marismortui) | Hmal4, Hl6 |
| 7 | G (E) | 50S ribosomal protein L6P | polymer | 178 | 19961.7 | 1 | UniProt (P14135) Pfam (PF00347) | Haloarcula marismortui (Halobacterium marismortui) | Hmal5, Hl13 |
| 8 | H (F) | 50S ribosomal protein L7Ae | polymer | 120 | 12791.9 | 1 | UniProt (P12743) Pfam (PF01248) | Haloarcula marismortui (Halobacterium marismortui) | Hmal6, Hl10 |
| 9 | I (G) | 50S ribosomal protein L10E | polymer | 348 | 37169.8 | 1 | UniProt (P15825) Pfam (PF00466) Pfam (PF17777) | Haloarcula marismortui (Halobacterium marismortui) | Hs6 |
| 10 | J (H) | 50S ribosomal protein L10e | polymer | 177 | 19942.7 | 1 | UniProt (P60617) Pfam (PF00252) | Haloarcula marismortui (Halobacterium marismortui) | Ribosomal protein L10, Acidic ribosomal protein P0 homolog, L10E, HMal10 |
| 11 | K (I) | 50S ribosomal protein L13P | polymer | 145 | 16249.2 | 1 | UniProt (P29198) Pfam (PF00572) | Haloarcula marismortui (Halobacterium marismortui) | |
| 12 | L (J) | 50S ribosomal protein L14P | polymer | 132 | 14216.2 | 1 | UniProt (P22450) Pfam (PF00238) | Haloarcula marismortui (Halobacterium marismortui) | Hmal13 |
| 13 | M (K) | 50S ribosomal protein L15P | polymer | 165 | 18005.4 | 1 | UniProt (P12737) Pfam (PF00828) | Haloarcula marismortui (Halobacterium marismortui) | Hmal14, Hl27 |
| 14 | N (L) | 50S ribosomal protein L15e | polymer | 196 | 22404.3 | 1 | UniProt (P60618) Pfam (PF00827) | Haloarcula marismortui (Halobacterium marismortui) | Hmal15, Hl9 |
| 15 | O (M) | 50S ribosomal protein L18P | polymer | 187 | 20640.9 | 1 | UniProt (P14123) Pfam (PF17144) | Haloarcula marismortui (Halobacterium marismortui) | 50S ribosomal protein LC12 |
| 16 | P (N) | 50S ribosomal protein L18e | polymer | 116 | 12438.9 | 1 | UniProt (P12733) Pfam (PF00828) | Haloarcula marismortui (Halobacterium marismortui) | Hmal18, Hl12 |
| 17 | Q (O) | 50S ribosomal protein L19e | polymer | 149 | 16796.5 | 1 | UniProt (P14119) Pfam (PF01280) | Haloarcula marismortui (Halobacterium marismortui) | Hl29, L19 |
| 18 | R (P) | 50S ribosomal protein L21e | polymer | 96 | 10567.8 | 1 | UniProt (P12734) Pfam (PF01157) | Haloarcula marismortui (Halobacterium marismortui) | Hmal19, Hl24 |
| 19 | S (Q) | 50S ribosomal protein L22P | polymer | 155 | 16966.9 | 1 | UniProt (P10970) Pfam (PF00237) | Haloarcula marismortui (Halobacterium marismortui) | Hl31 |
| 20 | T (R) | 50S ribosomal protein L23P | polymer | 85 | 9612.5 | 1 | UniProt (P12732) Pfam (PF00276) | Haloarcula marismortui (Halobacterium marismortui) | Hmal22, Hl23 |
| 21 | U (S) | 50S ribosomal protein L24P | polymer | 120 | 13671.0 | 1 | UniProt (P10972) Pfam (PF16906) Pfam (PF00467) | Haloarcula marismortui (Halobacterium marismortui) | Hmal23, Hl25, L21 |
| 22 | V (T) | 50S ribosomal protein L24e | polymer | 67 | 7364.9 | 1 | UniProt (P14116) Pfam (PF01246) | Haloarcula marismortui (Halobacterium marismortui) | Hmal24, Hl16, Hl15 |
| 23 | W (U) | 50S ribosomal protein L29P | polymer | 71 | 7889.9 | 1 | UniProt (P10971) Pfam (PF00831) | Haloarcula marismortui (Halobacterium marismortui) | Hl21/Hl22 |
| 24 | X (V) | 50S ribosomal protein L30P | polymer | 154 | 17062.9 | 1 | UniProt (P14121) Pfam (PF00327) | Haloarcula marismortui (Halobacterium marismortui) | Hmal29, Hl33 |
| 25 | Y (W) | 50S ribosomal protein L31e | polymer | 92 | 10384.6 | 1 | UniProt (P18138) Pfam (PF01198) | Haloarcula marismortui (Halobacterium marismortui) | Hmal30, Hl20, Hl16 |
| 26 | Z (X) | 50S ribosomal protein L32e | polymer | 241 | 26455.7 | 1 | UniProt (P12736) Pfam (PF14520) Pfam (PF01655) | Haloarcula marismortui (Halobacterium marismortui) | L34, Hl30 |
| 27 | AA (Y) | 50S ribosomal protein L37Ae | polymer | 92 | 10189.2 | 1 | UniProt (P60619) Pfam (PF01780) | Haloarcula marismortui (Halobacterium marismortui) | Hl5 |
| 28 | BA (Z) | 50S ribosomal protein L37e | polymer | 57 | 6330.2 | 1 | UniProt (P32410) Pfam (PF01907) | Haloarcula marismortui (Halobacterium marismortui) | |
| 29 | CA (1) | 50S ribosomal protein L39e | polymer | 50 | 6133.1 | 1 | UniProt (P22452) Pfam (PF00832) | Haloarcula marismortui (Halobacterium marismortui) | L35e |
| 30 | DA (2) | 50S ribosomal protein L44E | polymer | 92 | 10815.2 | 1 | UniProt (P32411) Pfam (PF00935) | Haloarcula marismortui (Halobacterium marismortui) | Hl39e, Hl46e |
| 31 | EA (4) | 5'-R(*CP*CP*AP*(PHE)*(ACA))-3' | polymer | 4 | 1041.8 | 1 | Haloarcula marismortui (Halobacterium marismortui) | La, Hla | |
| 32 | FA (0) | N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide | non-polymer | 337.3 | 1 | Chemie (ZLD) | |||
| 33 | AB, AC, AD, BB, BC... (0, A, B, S, X...) | MAGNESIUM ION | non-polymer | 24.3 | 92 | Chemie (MG) | |||
| 34 | MD, ND (0) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 35 | AE, AF, BE, BF, CE... (0, P, Q, R, B...) | SODIUM ION | non-polymer | 23.0 | 75 | Chemie (NA) | |||
| 36 | AG, AL, BG, BL, CG... (0, L, M, N, A...) | CHLORIDE ION | non-polymer | 35.5 | 22 | Chemie (CL) | |||
| 37 | AH, AI, AJ, AK, BH... (0, 9, A, Q, R...) | STRONTIUM ION | non-polymer | 87.6 | 108 | Chemie (SR) | |||
| 38 | CL, NL, QL, RL, VL (N, T, Y, Z, 2) | CADMIUM ION | non-polymer | 112.4 | 5 | Chemie (CD) | |||
| 39 | YL (4) | ACETYL GROUP | non-polymer | 44.1 | 1 | Chemie (ACE) | |||
| 40 | AM, AN, BM, BN, CM... (9, Z, A, 1, B...) | water | water | 18.0 | 7762 | Chemie (HOH) |
Sequence modifications
0: 2 - 2923 (GenBank: 3377779)
| PDB | External Database | Details |
|---|---|---|
| C 559 | U 3154 | conflict |
| C 560 | U 3155 | conflict |
| A 2099 | G 4694 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 31 |
| Total formula weight | 1459199.1 | |
| Non-Polymers* | Number of molecules | 306 |
| Total formula weight | 15224.9 | |
| All* | Total formula weight | 1474424.0 |
