3CPW

The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	0	23S RIBOSOMAL RNA	polymer	2922	946017.4	1	GenBank (3377779)	HALOARCULA MARISMORTUI
2	9	5S RIBOSOMAL RNA	polymer	122	39318.4	1	GenBank (3377779)	HALOARCULA MARISMORTUI
3	A	50S ribosomal protein L2P	polymer	240	25354.7	1	UniProt (P20276) Pfam (PF00181) Pfam (PF03947) In PDB	Haloarcula marismortui (Halobacterium marismortui)
4	B	50S ribosomal protein L3P	polymer	338	37396.4	1	UniProt (P20279) Pfam (PF00297) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal2, Hl4
5	C	50S ribosomal protein L4P	polymer	246	26457.1	1	UniProt (P12735) Pfam (PF00573) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal3, Hl1
6	D	50S ribosomal protein L5P	polymer	177	19551.7	1	UniProt (P14124) Pfam (PF00281) Pfam (PF00673) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal4, Hl6
7	E	50S ribosomal protein L6P	polymer	178	19961.7	1	UniProt (P14135) Pfam (PF00347) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal5, Hl13
8	F	50S ribosomal protein L7Ae	polymer	120	12791.9	1	UniProt (P12743) Pfam (PF01248) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal6, Hl10
9	G	50S ribosomal protein L10E	polymer	348	37169.8	1	UniProt (P15825) Pfam (PF00466) Pfam (PF17777) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hs6
10	H	50S ribosomal protein L10e	polymer	177	19942.7	1	UniProt (P60617) Pfam (PF00252) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Ribosomal protein L10, Acidic ribosomal protein P0 homolog, L10E, HMal10
11	I	50S ribosomal protein L13P	polymer	145	16249.2	1	UniProt (P29198) Pfam (PF00572) In PDB	Haloarcula marismortui (Halobacterium marismortui)
12	J	50S ribosomal protein L14P	polymer	132	14216.2	1	UniProt (P22450) Pfam (PF00238) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal13
13	K	50S ribosomal protein L15P	polymer	165	18005.4	1	UniProt (P12737) Pfam (PF00828) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal14, Hl27
14	L	50S ribosomal protein L15e	polymer	196	22404.3	1	UniProt (P60618) Pfam (PF00827) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal15, Hl9
15	M	50S ribosomal protein L18P	polymer	187	20640.9	1	UniProt (P14123) Pfam (PF17144) In PDB	Haloarcula marismortui (Halobacterium marismortui)	50S ribosomal protein LC12
16	N	50S ribosomal protein L18e	polymer	116	12438.9	1	UniProt (P12733) Pfam (PF00828) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal18, Hl12
17	O	50S ribosomal protein L19e	polymer	149	16796.5	1	UniProt (P14119) Pfam (PF01280) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hl29, L19
18	P	50S ribosomal protein L21e	polymer	96	10567.8	1	UniProt (P12734) Pfam (PF01157) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal19, Hl24
19	Q	50S ribosomal protein L22P	polymer	155	16966.9	1	UniProt (P10970) Pfam (PF00237) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hl31
20	R	50S ribosomal protein L23P	polymer	85	9612.5	1	UniProt (P12732) Pfam (PF00276) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal22, Hl23
21	S	50S ribosomal protein L24P	polymer	120	13671.0	1	UniProt (P10972) Pfam (PF16906) Pfam (PF00467) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal23, Hl25, L21
22	T	50S ribosomal protein L24e	polymer	67	7364.9	1	UniProt (P14116) Pfam (PF01246) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal24, Hl16, Hl15
23	U	50S ribosomal protein L29P	polymer	71	7889.9	1	UniProt (P10971) Pfam (PF00831) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hl21/Hl22
24	V	50S ribosomal protein L30P	polymer	154	17062.9	1	UniProt (P14121) Pfam (PF00327) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal29, Hl33
25	W	50S ribosomal protein L31e	polymer	92	10384.6	1	UniProt (P18138) Pfam (PF01198) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hmal30, Hl20, Hl16
26	X	50S ribosomal protein L32e	polymer	241	26455.7	1	UniProt (P12736) Pfam (PF14520) Pfam (PF01655) In PDB	Haloarcula marismortui (Halobacterium marismortui)	L34, Hl30
27	Y	50S ribosomal protein L37Ae	polymer	92	10189.2	1	UniProt (P60619) Pfam (PF01780) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hl5
28	Z	50S ribosomal protein L37e	polymer	57	6330.2	1	UniProt (P32410) Pfam (PF01907) In PDB	Haloarcula marismortui (Halobacterium marismortui)
29	1	50S ribosomal protein L39e	polymer	50	6133.1	1	UniProt (P22452) Pfam (PF00832) In PDB	Haloarcula marismortui (Halobacterium marismortui)	L35e
30	2	50S ribosomal protein L44E	polymer	92	10815.2	1	UniProt (P32411) Pfam (PF00935) In PDB	Haloarcula marismortui (Halobacterium marismortui)	Hl39e, Hl46e
31	4	5'-R(*CP*CP*AP*(PHE)*(ACA))-3'	polymer	4	1041.8	1		Haloarcula marismortui (Halobacterium marismortui)	La, Hla
32	0	N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide	non-polymer		337.3	1	Chemie (ZLD)
33	0, A, B, S, X...	MAGNESIUM ION	non-polymer		24.3	92	Chemie (MG)
34	0	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
35	0, P, Q, R, B...	SODIUM ION	non-polymer		23.0	75	Chemie (NA)
36	0, L, M, N, A...	CHLORIDE ION	non-polymer		35.5	22	Chemie (CL)
37	0, 9, A, Q, R...	STRONTIUM ION	non-polymer		87.6	108	Chemie (SR)
38	N, T, Y, Z, 2	CADMIUM ION	non-polymer		112.4	5	Chemie (CD)
39	4	ACETYL GROUP	non-polymer		44.1	1	Chemie (ACE)
40		water	water		18.0	7762	Chemie (HOH)

Sequence modifications

0: 2 - 2923 (GenBank: 3377779)

PDB	External Database	Details
C 559	U 3154	conflict
C 560	U 3155	conflict
A 2099	G 4694	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	31
	Total formula weight	1459199.1
Non-Polymers*	Number of molecules	306
	Total formula weight	15224.9
All*	Total formula weight	1474424.0

*Water molecules are not included.