3CON

Crystal structure of the human NRAS GTPase bound with GDP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	GTPase NRas	polymer	190	21771.6	1	UniProt (P01111) Pfam (PF00071)	Homo sapiens (human)	Transforming protein N-Ras
2	B, C, D, E (A)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
3	F (A)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)
4	G, H, I, J, K... (A)	UNKNOWN ATOM OR ION	non-polymer			8	Chemie (UNX)
5	O (A)	water	water		18.0	84	Chemie (HOH)

Sequence modifications

A: 1 - 172 (UniProt: P01111)

PDB	External Database	Details
Met -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Arg -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	21771.6
Non-Polymers*	Number of molecules	13
	Total formula weight	540.4
All*	Total formula weight	22312.0

*Water molecules are not included.