3CON

Crystal structure of the human NRAS GTPase bound with GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0001938	biological_process	positive regulation of endothelial cell proliferation
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0007265	biological_process	Ras protein signal transduction
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0044877	molecular_function	protein-containing complex binding
A	0070062	cellular_component	extracellular exosome
A	0070821	cellular_component	tertiary granule membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 202

Chain	Residue
A	SER17
A	HOH226
A	HOH265
A	HOH279
A	HOH282

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 203

Chain	Residue
A	HOH252
A	HOH278
A	GLY48
A	HOH247
A	HOH249
A	HOH250

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 204

Chain	Residue
A	ASP38
A	HOH280
A	HOH283
A	HOH284
A	HOH294

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 205

Chain	Residue
A	HOH231
A	HOH245

---

site_id	AC5
Number of Residues	23
Details	BINDING SITE FOR RESIDUE GDP A 201

Chain	Residue
A	GLY13
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	ASP30
A	TYR32
A	ASN116
A	LYS117
A	ASP119
A	LEU120
A	SER145
A	ALA146
A	LYS147
A	HOH221
A	HOH235
A	HOH270
A	HOH273
A	HOH279
A	HOH282
A	HOH290
A	HOH291

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 206

Chain	Residue
A	ASP47
A	ARG102

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 207

Chain	Residue
A	LEU6
A	ASP54

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE UNX A 208

Chain	Residue
A	GLY10
A	THR58
A	TYR96
A	HOH234
A	HOH236

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UNX A 209

Chain	Residue
A	GLY10
A	ALA11
A	SER89

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE UNX A 200

Chain	Residue
A	GLU31
A	ARG149
A	GLU153
A	HOH219

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE UNX A 211

Chain	Residue
A	SER87
A	LYS88
A	THR124
A	HOH217

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UNX A 212

Chain	Residue
A	ASN94
A	LEU95
A	HOH233

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 213

Chain	Residue
A	ASP154
A	ARG161

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|Ref.29

Chain	Residue	Details
A	GLY10
A	VAL29
A	ASN116

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	ASP57

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by STK19 => ECO:0000269|PubMed:30712867

Chain	Residue	Details
A	SER89

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486

Chain	Residue	Details
A	THR35

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:30442762

Chain	Residue	Details
A	LYS170

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