3CON
Crystal structure of the human NRAS GTPase bound with GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000164 | cellular_component | protein phosphatase type 1 complex |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001938 | biological_process | positive regulation of endothelial cell proliferation |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007265 | biological_process | Ras protein signal transduction |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0046579 | biological_process | positive regulation of Ras protein signal transduction |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070821 | cellular_component | tertiary granule membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 202 |
| Chain | Residue |
| A | SER17 |
| A | HOH226 |
| A | HOH265 |
| A | HOH279 |
| A | HOH282 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 203 |
| Chain | Residue |
| A | HOH252 |
| A | HOH278 |
| A | GLY48 |
| A | HOH247 |
| A | HOH249 |
| A | HOH250 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 204 |
| Chain | Residue |
| A | ASP38 |
| A | HOH280 |
| A | HOH283 |
| A | HOH284 |
| A | HOH294 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 205 |
| Chain | Residue |
| A | HOH231 |
| A | HOH245 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE GDP A 201 |
| Chain | Residue |
| A | GLY13 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | ASP30 |
| A | TYR32 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | LYS147 |
| A | HOH221 |
| A | HOH235 |
| A | HOH270 |
| A | HOH273 |
| A | HOH279 |
| A | HOH282 |
| A | HOH290 |
| A | HOH291 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 206 |
| Chain | Residue |
| A | ASP47 |
| A | ARG102 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 207 |
| Chain | Residue |
| A | LEU6 |
| A | ASP54 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE UNX A 208 |
| Chain | Residue |
| A | GLY10 |
| A | THR58 |
| A | TYR96 |
| A | HOH234 |
| A | HOH236 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX A 209 |
| Chain | Residue |
| A | GLY10 |
| A | ALA11 |
| A | SER89 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX A 200 |
| Chain | Residue |
| A | GLU31 |
| A | ARG149 |
| A | GLU153 |
| A | HOH219 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX A 211 |
| Chain | Residue |
| A | SER87 |
| A | LYS88 |
| A | THR124 |
| A | HOH217 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX A 212 |
| Chain | Residue |
| A | ASN94 |
| A | LEU95 |
| A | HOH233 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 213 |
| Chain | Residue |
| A | ASP154 |
| A | ARG161 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of the human NRAS GTPase bound with GDP.","authors":["Nedyalkova L.","Tong Y.","Tempel W.","Shen L.","Loppnau P.","Arrowsmith C.H.","Edwards A.M.","Bountra C.","Weigelt J.","Bochkarev A.","Park H."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30712867","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
